Evidence map›Paper›PMID 36513496›Full record

ReviewObesity (Silver Spring, Md.)2023

Finding balance: understanding the energetics of time-restricted feeding in mice.

Molly R Gallop, Selene Y Tobin, Amandine Chaix

Open access · greenAbstract readReview
In one paragraph

Review in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Molly R GallopDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Selene Y TobinDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Amandine ChaixDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-7007-197X
University of Utah · US

Funding

University of Utah Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism ResearchT32DK110966 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck, Marcus Guy Pezzolesi · 2016 to 2026
$2.6M
Mechanisms by which time-restricted feeding (TRF) delays the onset of age-related declines in health, cognition, and circadian rhythmsR01AG065993 · NIA · UNIVERSITY OF UTAH · PI CHAIX, AMANDINE H. · 2019 to 2023
$2.1M
NRSA Training CoreTL1TR002540 · NCATS · UNIVERSITY OF UTAH · PI FAGERLIN, ANGELA, FAIRFAX, KEKE CELESTE · 2018 to 2022
$1.6M
CTSA Predoctoral T32 at University of Utah: Spheres of Translation Across the Research Spectrum (STARS) Training ProgramT32TR004392 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ANGELA FAGERLIN, Keke Celeste Fairfax · 2023 to 2026
$1.3M
NCATS NIH HHS T32 TR004392NCATS NIH HHS TL1 TR002540NIA NIH HHS R01 AG065993NIDDK NIH HHS T32 DK110966
6 · The paper itself

Abstract

Over the course of mammalian evolution, the ability to store energy likely conferred a survival advantage when food became scarce. A long-term increase in energy storage results from an imbalance between energy intake and energy expenditure, two tightly regulated parameters that generally balance out to maintain a fairly stable body weight. Understanding the molecular determinants of this feat likely holds the key to new therapeutic development to manage obesity and associated metabolic dysfunctions. Time-restricted feeding (TRF), a dietary intervention that limits feeding to the active phase, can prevent and treat obesity and metabolic dysfunction in rodents fed a high-fat diet, likely by exerting effects on energetic balance. Even when body weight is lower in mice on active-phase TRF, food intake is generally isocaloric as compared with ad libitum fed controls. This discrepancy between body weight and energy intake led to the hypothesis that energy expenditure is increased during TRF. However, at present, there is no consensus in the literature as to how TRF affects energy expenditure and energy balance as a whole, and the mechanisms behind metabolic adaptation under TRF are unknown. This review examines our current understanding of energy balance on TRF in rodents and provides a framework for future studies to evaluate the energetics of TRF and its molecular determinants.

Indexed as

Energy IntakeObesityAnimalsBody WeightDiet, High-FatEnergy MetabolismMammalsMice

Identifiers

PMID36513496
PMCPMC9877167
OpenAlexW4311305214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.