ArticleJournal of advanced research2022
Comparison of dynamic 3D chromatin architecture uncovers heterosis for leaf size in Brassica napus.
Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- 3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The epigenetic landscape of heterosis: integrating multi-layer regulatory insights and navigating the path to causality.Frontiers in plant science · 2026Review
- Genomic and epigenomic coordination maintains subgenome transcriptional balance in allotetraploidHorticulture research · 2026Article
- Conservation and variability of long-range interactions in structurally diverse maize genomes.Nature communications · 2025Article
- The Association Between DNA Methylation and Three-Dimensional Genome During Whole Genome Doubling inPlants (Basel, Switzerland) · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Insights into heterosis from histone modifications in the flag leaf of inter-subspecific hybrid rice.BMC plant biology · 2024Article
- BL-Hi-C reveals the 3D genome structure ofHorticulture research · 2024Article
- Integrating Dynamic 3D Chromatin Architecture and Gene Expression Alterations Reveal Heterosis inInternational journal of molecular sciences · 2024Article
- Review
- 3D genome structural variations play important roles in regulating seed oil content of Brassica napus.Plant communications · 2024Article
- Comparative transcriptomic analysis reveals the molecular mechanism underlying seedling heterosis and its relationship with hybrid contemporary seeds DNA methylation in soybean.Frontiers in plant science · 2024Article
- Genome-wide association study of leaf-related traits in tea plant in Guizhou based on genotyping-by-sequencing.BMC plant biology · 2023Article
- Comparative transcriptomic analysis reveals the molecular mechanism underlying seedling biomass heterosis in Brassica napus.BMC plant biology · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHeterosis is the major event driving plant development and promoting crop breeding, but the molecular bases for this phenomenon remain elusive.
objectivesWe aim to explore the effect of three-dimensional (3D) chromatin architecture on the underlying mechanism of heterosis.
methodsHere, we constructed the North Carolina II (NC-II) population to select superior and inferior heterosis sets by comparing mid-parent heterosis (MPH) in Brassica napus. To decipher the impact of 3D chromatin architecture on the underlying mechanism of heterosis, we combined genetics, transcriptomics and 3D genomics approaches.
resultsWe suggest that F1 hybrids with superior heterosis tend to contain more transcriptionally active A compartments compared with F1 hybrids with inferior heterosis, and approximately 19-21% compartment significantly altered in the F1 hybrids relative to the parental lines. Further analyses show that chromatin compartments correlate with genetic variance among parents, which may form the basis for differentially active chromatin compartments. Having more A compartments in F1 hybrids confers a more accessible chromatin circumstance, which promotes a higher proportion of highly expressed ELD (expression level dominance) genes in superior heterosis F1 hybrids (46-64%) compared with inferior heterosis F1 hybrids (22-31%). Moreover, genes related to hormones which affect plant growth, are more up-regulated with changes of 3D genome architecture, and we validate that increased hormone content contributes to cell proliferation and expansion by influencing the key genes of cell cycle thereby promoting leaf size.
conclusionDynamic 3D chromatin architecture correlates with genetic variance among parents and contributes to heterosis in Brassica napus.
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