ArticleJournal of advanced research2022
A varied AvrXa23-like TALE enables the bacterial blight pathogen to avoid being trapped by Xa23 resistance gene in rice.
Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- The Rice-Xoc Arms Race: Molecular Mechanisms and Genomic Strategies Against Bacterial Leaf Streak.Rice (New York, N.Y.) · 2026Review
- Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Effector Triggered Susceptibility and Immunity in Bacterial Diseases of Leaf Blight and Streak in Rice.Rice (New York, N.Y.) · 2026Review
- Resistance gene againstFrontiers in plant science · 2026Review
- Rice phyllospheric Pantoea spp. suppress blast and bacterial blight diseases.Environmental microbiome · 2025Article
- An altruistic rhizo-microbiome strategy in crop-rotation systems for sustainable management of soil-borne diseases.Plant communications · 2025Article
- Activity-based protein profiling guided new target identification of quinazoline derivatives for expediting bactericide discovery: Activity-based protein profiling derived new target discovery of antibacterial quinazolines.Journal of advanced research · 2025Article
- Transcription activator-like effectors of Xanthomonas oryzae pv. oryzae hijack host transcriptional regulation through OsWRKYs.Journal of integrative plant biology · 2025Article
- Efficient Marker-Assisted Pyramiding ofPlants (Basel, Switzerland) · 2025Article
- Microbiome Engineering for Sustainable Rice Production: Strategies for Biofertilization, Stress Tolerance, and Climate Resilience.Microorganisms · 2025Review
- Complete genome and comparative analysis of Xanthomonas oryzae pv. oryzae isolated from northern Thailand.Access microbiology · 2025Article
- Comparative genomics using long-read sequencing identifies nearly identical TAL effector regions in twoFrontiers in microbiology · 2025Article
- A new bacterial blight resistance geneFrontiers in plant science · 2025Article
- Identification and Genome Sequencing of Novel Virulent Strains ofPathogens (Basel, Switzerland) · 2024Article
- Transcriptome Analysis of Rice Near-Isogenic Lines Inoculated with Two Strains ofPlants (Basel, Switzerland) · 2024Article
- Transcriptome and Metabolome Analysis of Rice Cultivar CBB23 after Inoculation byPlants (Basel, Switzerland) · 2024Article
- Constructed Rice Tracers Identify the Major Virulent Transcription Activator-Like Effectors of the Bacterial Leaf Blight Pathogen.Rice (New York, N.Y.) · 2024Article
- Genome editing of a dominant resistance gene for broad-spectrum resistance to bacterial diseases in rice without growth penalty.Plant biotechnology journal · 2024Article
- Tal6b/AvrXa27A, a hidden TALE targeting the susceptibility gene OsSWEET11a and the resistance gene Xa27 in rice.Plant communications · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionXa23 as an executor mediates broad-spectrum resistance to Xanthomonas oryzae pv. oryzae (Xoo), which contains a matching avirulence gene avrXa23, in rice for bacterial leaf blight (BLB). avrXa23 encodes a transcription activator-like effector (TALE) protein which binds to the EBE (effector-binding element) of the Xa23 promoter. It is unclear whether the considerable pressure of Xa23 leads to an emerging Xoo strain that overcomes Xa23 resistance.
objectivesThis study aimed to uncover new Xoo isolate(s) that overcome Xa23-mediated resistance and to investigate how the pathogen evades the resistance.
methodsTotally 185 Xoo isolates were used to screen possibly compatible strain(s) with Xa23-containing rice CBB23 by pathogenicity test. Genome Sequencing, Southern blot, tal gene cloning, Western blot, qRT-PCR and electrophoretic mobility shift assays (EMSA) were conducted to determine the mechanism of one Xoo isolate being compatible with Xa23-containing rice.
resultsOne isolate AH28 from Anhui province is compatible with CBB23. AH28 strain contains an ortholog of avrXa23, tal7b and has 17 tal genes. The 4th RVD (repeat-variable diresidue) in Tal7b are missed and the 5th and 8th RVDs changed from NG and NS to NS and S*, respectively. These alternations made Tal7b unable to bind to the EBE of Xa23 promoter to activate the expression of Xa23 in rice. The ectopic expression of tal7b in a tal-free mutant PH of PXO99
conclusionBest to our knowledge, this is the first insight of a naturally-emerging Xoo isolate that overcomes the broad-spectrum resistance of Xa23 by the variable AvrXa23-like TALE Tal7b. The RVD alteration in AvrXa23 may be a common strategy for the pathogen evolution to avoid being "trapped" by the executor R gene.
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