ArticleMathematical biosciences2023
Conditions for Kir-induced bistability of membrane potential in capillary endothelial cells.
Article in Mathematical biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 2 citations in OpenAlex.
- Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability.PLoS computational biology · 2026Article
- Voltage-Dependent Ion Channels in Vascular Endothelial Cells: An Unexpected Signaling Pathway in Non-Excitable Cells.Biomedicines · 2026Review
- Simulation of Conducted Responses in Microvascular Networks: Role of Gap Junction Current Rectification.Microcirculation (New York, N.Y. : 1994) · 2025Article
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2 authors at 1 institution in 1 country.
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Abstract
A simplified model for electrophysiology of endothelial cells is used to examine the conditions that can lead to bistability of membrane resting potential. The model includes the effects of inward-rectifying potassium (Kir) ion channels, whose current-voltage relationship shows an interval of negative slope and whose maximum conductance is dependent on the extracellular potassium concentration. The background current resulting from other types of channels is assumed to be linearly related to membrane potential. A method is presented for identifying the boundaries in the parameter space for the background currents of the regions of bistability. It is shown that these regions are relatively narrow and depend on extracellular potassium concentration. The results are used to define conditions leading to transitions between depolarized and hyperpolarized membrane states. These behaviors can influence the properties of conducted responses, in which changes in membrane potential are propagated along blood vessel walls. Conducted responses are important in the local regulation of blood flow in the brain and other tissues.
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