Evidence map›Paper›PMID 36512941›Full record

ArticleMedical image analysis2023

Unsupervised cross-domain functional MRI adaptation for automated major depressive disorder identification.

Yuqi Fang, Mingliang Wang, Guy G Potter, Mingxia Liu

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Source-free unsupervised domain adaptation: A survey.Neural networks : the official journal of the International Neural Network Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Yuqi FangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Mingliang WangSchool of Computer and Software, Nanjing University of Information Science and Technology, Nanjing 210044, China.
Guy G PotterDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: guy.potter@duke.edu.
Mingxia LiuDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address: mxliu@med.unc.edu.
University of North Carolina at Chapel Hill · USDuke University · USNanjing University of Information Science and Technology · CN

Funding

2/2 Phenotype Predictors of Cognitive Outcomes in Geriatric DepressionR01MH108560 · NIMH · DUKE UNIVERSITY · PI POTTER, GUY GLENN · 2016 to 2020
$1.8M
Multi-Site Neuroimage Harmonization for Personalized Brain Disorder AnalysisRF1AG073297 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2022 to 2022
$1.4M
NIA NIH HHS RF1 AG073297NIMH NIH HHS R01 MH108560
6 · The paper itself

Abstract

Resting-state functional magnetic resonance imaging (rs-fMRI) data have been widely used for automated diagnosis of brain disorders such as major depressive disorder (MDD) to assist in timely intervention. Multi-site fMRI data have been increasingly employed to augment sample size and improve statistical power for investigating MDD. However, previous studies usually suffer from significant inter-site heterogeneity caused for instance by differences in scanners and/or scanning protocols. To address this issue, we develop a novel discrepancy-based unsupervised cross-domain fMRI adaptation framework (called UFA-Net) for automated MDD identification. The proposed UFA-Net is designed to model spatio-temporal fMRI patterns of labeled source and unlabeled target samples via an attention-guided graph convolution module, and also leverage a maximum mean discrepancy constrained module for unsupervised cross-site feature alignment between two domains. To the best of our knowledge, this is one of the first attempts to explore unsupervised rs-fMRI adaptation for cross-site MDD identification. Extensive evaluation on 681 subjects from two imaging sites shows that the proposed method outperforms several state-of-the-art methods. Our method helps localize disease-associated functional connectivity abnormalities and is therefore well interpretable and can facilitate fMRI-based analysis of MDD in clinical practice.

Indexed as

Major Depressive DisorderBrainHumansMagnetic Resonance ImagingFunctional MRIGraph convolutional networkMajor depressive disorderUnsupervised domain adaptation

Identifiers

PMID36512941
PMCPMC9850278
OpenAlexW4310261818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.