Evidence map›Paper›PMID 36512724›Full record

ArticleAnesthesiology2023

Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study.

Jamie R Privratsky, Matthew Fuller, Karthik Raghunathan, Tetsu Ohnuma, Raquel R Bartz, Rebecca Schroeder, Thomas M Price, Michael R Martinez, Martin I Sigurdsson, Michael R Mathis and 2 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 4 countries.

Jamie R PrivratskyCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, and Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.ORCID 0000-0003-3598-4911
Matthew FullerCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
Karthik RaghunathanCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina; and Durham Veterans Administration Medical Center, Durham, North Carolina.
Tetsu OhnumaCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
Raquel R BartzCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
Rebecca SchroederCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina; and Durham Veterans Administration Medical Center, Durham, North Carolina.
Thomas M PriceDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
Michael R MartinezCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
Martin I SigurdssonDivision of Anesthesia and Intensive Care Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; and University of Iceland, Reykjavik, Iceland.
Michael R MathisDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan.
Bhiken NaikDepartment of Anesthesiology, University of Virginia, Charlottesville, Virginia.
Vijay KrishnamoorthyCritical Care and Perioperative Population Health Research Unit, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
Duke University · USSchool of the Art Institute of Chicago · US

Funding

Cardiac sURgery anesthesia Best practices to reduce Acute Kidney Injury (CURB-AKI)R01DK133226 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Robert Mathis, Karandeep Singh · 2022 to 2026
$3.3M
Novel mitochondrial protective properties of annexin A1R01DK131065 · NIDDK · DUKE UNIVERSITY · PI PRIVRATSKY, JAMIE R · 2021 to 2025
$1.6M
The Role of the IL-1 Receptor in the AKI to CKD transitionK08GM132689 · NIGMS · DUKE UNIVERSITY · PI PRIVRATSKY, JAMIE R · 2019 to 2023
$900k
Early Diagnosis of Heart Failure: A Perioperative Data-Driven ApproachK01HL141701 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATHIS, MICHAEL ROBERT · 2018 to 2022
$862k
NHLBI NIH HHS K01 HL141701NIDDK NIH HHS R01 DK131065NIDDK NIH HHS R01 DK133226NIGMS NIH HHS K08 GM132689
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) after noncardiac surgery is common and has substantial health impact. Preclinical and clinical studies examining the influence of sex on AKI have yielded conflicting results, although they typically do not account for age-related changes. The objective of the study was to determine the association of age and sex groups on postoperative AKI. The authors hypothesized that younger females would display lower risk of postoperative AKI than males of similar age, and the protection would be lost in older females.

methodsThis was a multicenter retrospective cohort study across 46 institutions between 2013 and 2019. Participants included adult inpatients without pre-existing end-stage kidney disease undergoing index major noncardiac, nonkidney/urologic surgeries. The authors' primary exposure was age and sex groups defined as females 50 yr or younger, females older than 50 yr, males 50 yr or younger, and males older than 50 yr. The authors' primary outcome was development of AKI by Kidney Disease-Improving Global Outcomes serum creatinine criteria. Exploratory analyses included associations of ascending age groups and hormone replacement therapy home medications with postoperative AKI.

resultsAmong 390,382 patients, 25,809 (6.6%) developed postoperative AKI (females 50 yr or younger: 2,190 of 58,585 [3.7%]; females older than 50 yr: 9,320 of 14,4047 [6.5%]; males 50 yr or younger: 3,289 of 55,503 [5.9%]; males older than 50 yr: 11,010 of 132,447 [8.3%]). When adjusted for AKI risk factors, compared to females younger than 50 yr (odds ratio, 1), the odds of AKI were higher in females older than 50 yr (odds ratio, 1.51; 95% CI, 1.43 to 1.59), males younger than 50 yr (odds ratio, 1.90; 95% CI, 1.79 to 2.01), and males older than 50 yr (odds ratio, 2.06; 95% CI, 1.96 to 2.17).

conclusionsYounger females display a lower odds of postoperative AKI that gradually increases with age. These results suggest that age-related changes in women should be further studied as modifiers of postoperative AKI risk after noncardiac surgery. EDITOR’S PERSPECTIVE:

Indexed as

Acute Kidney InjuryKidney Failure, ChronicAdultAgedCreatinineFemaleHumansMalePostoperative ComplicationsRetrospective StudiesRisk FactorsCreatinine

Identifiers

PMID36512724
PMCPMC10439699
OpenAlexW4309648737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.