Evidence map›Paper›PMID 36512497›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia.

Soojin Kim, Seong-Wook Kim, Mai Anh Thi Bui, Yeji Kim, Minsoo Kim, Jung-Cheol Park, Nam-Heon Kim, Gyeong Hee Pyeon, Yong Sang Jo, Jaewon Jang and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 2 countries.

Soojin KimGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Seong-Wook KimGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.ORCID 0000-0002-8928-290X
Mai Anh Thi BuiGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Yeji KimResearch Center for Convergence Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.ORCID 0000-0002-7675-1092
Minsoo KimGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.ORCID 0000-0002-2228-5874
Jung-Cheol ParkDepartment of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.
Nam-Heon KimDepartment of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0000-0002-7605-2910
Gyeong Hee PyeonSchool of Psychology, Korea University, Seoul 02841, Republic of Korea.
Yong Sang JoSchool of Psychology, Korea University, Seoul 02841, Republic of Korea.ORCID 0000-0002-7716-0964
Jaewon JangCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02455, Republic of Korea.
Hae-Young KohCenter for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02455, Republic of Korea.
Chae-Hong JeongGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.ORCID 0000-0001-6863-7575
Moonkyung KangGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Hyo Jung KangDepartment of Life Science, Chung-Ang University, Seoul 06911, Republic of Korea.
Yong-Woo LeeDepartment of Biomedical Laboratory Science, Inje University, Gimhae 50834, Republic of Korea.ORCID 0000-0003-4917-9139
Craig A StockmeierDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216.
Je Kyung SeongKorea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Republic of Korea.
Dong Ho WooResearch Center for Convergence Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.ORCID 0000-0003-3366-3831
Jung-Soo HanDepartment of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0000-0001-8447-4518
Yeon-Soo KimGraduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.ORCID 0000-0001-9343-7022
Chungnam National University · KRKonkuk University · KRKorea Institute of Brain Science · KRKorea University · KRChung-Ang University · KRInje University · KRKorea Institute of Toxicology · KRSeoul National University · KRUniversity of Mississippi Medical Center · US

Funding

Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
NIGMS NIH HHS P30 GM103328
6 · The paper itself

Abstract

The selenium-binding protein 1 (SELENBP1) has been reported to be up-regulated in the prefrontal cortex (PFC) of schizophrenia patients in postmortem reports. However, no causative link between SELENBP1 and schizophrenia has yet been established. Here, we provide evidence linking the upregulation of SELENBP1 in the PFC of mice with the negative symptoms of schizophrenia. We verified the levels of

Indexed as

SchizophreniaAnimalsBrainHumansMiceMice, TransgenicPrefrontal CortexPyramidal CellsSelenium-Binding ProteinsSELENBP1 protein, humanSelenbp1 protein, mouseSelenium-Binding ProteinsBrodmann area 9frontal cortexschizophreniaSELENBP1social behavior

Identifiers

PMID36512497
PMCPMC9907074
OpenAlexW4311341631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.