ArticleeLife2022
Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Modulation of Hamstrings Neural Drive During Isometric Contractions of the Hip Extensors and Knee Flexors.Scandinavian journal of medicine & science in sports · 2026Article
- Spinal circuits encode a map of the trunk to control skin twitches.bioRxiv : the preprint server for biology · 2026Article
- Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.Journal of neuroengineering and rehabilitation · 2025Article
- Article
- A cholinergic spinal pathway for the adaptive control of breathing.Cell reports · 2025Article
- A cholinergic spinal pathway for the adaptive control of breathing.bioRxiv : the preprint server for biology · 2025Article
- Quantifying the diverse contributions of hierarchical muscle interactions to motor function.iScience · 2025Article
- Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.eLife · 2024Article
- Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- A computational study of how an α- to γ-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An alpha- to gamma-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement: A computational study.bioRxiv : the preprint server for biology · 2024Article
- Review
- Hodological patterning as an organizing principle in vertebrate motor circuitry.Frontiers in neuroanatomy · 2024Review
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.Current opinion in neurobiology · 2023Review
- Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources.NeuroImage · 2023Article
- Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled.eLife · 2022Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Elaborate behaviours are produced by tightly controlled flexor-extensor motor neuron activation patterns. Motor neurons are regulated by a network of interneurons within the spinal cord, but the computational processes involved in motor control are not fully understood. The neuroanatomical arrangement of motor and premotor neurons into topographic patterns related to their controlled muscles is thought to facilitate how information is processed by spinal circuits. Rabies retrograde monosynaptic tracing has been used to label premotor interneurons innervating specific motor neuron pools, with previous studies reporting topographic mediolateral positional biases in flexor and extensor premotor interneurons. To more precisely define how premotor interneurons contacting specific motor pools are organized, we used multiple complementary viral-tracing approaches in mice to minimize systematic biases associated with each method. Contrary to expectations, we found that premotor interneurons contacting motor pools controlling flexion and extension of the ankle are highly intermingled rather than segregated into specific domains like motor neurons. Thus, premotor spinal neurons controlling different muscles process motor instructions in the absence of clear spatial patterns among the flexor-extensor circuit components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.