ArticleInvestigative ophthalmology & visual science2022
Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia.
Article in Investigative ophthalmology & visual science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 35 citations in OpenAlex.
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- Model of naturally occurring refractive error (NORE) in mice.bioRxiv : the preprint server for biology · 2026Article
- Short-Term Effects of Orthokeratology Treatment Zone Decentration on Choroidal Thickness and Vasculature.Translational vision science & technology · 2026Article
- Ocular rigidity in eyes with experimental myopia.Experimental eye research · 2026Article
- Aquaporin-1 upregulation is associated with scleral remodeling during myopia development in mice.American journal of translational research · 2026Article
- Pyroptosis-associated inflammasome activation contributes to scleral remodeling in experimental myopia.International journal of ophthalmology · 2026Article
- Examining murine eye length asymmetry with spectral domain optical coherence tomography.Experimental eye research · 2025Article
- AllJournal of the Royal Society, Interface · 2025Article
- Timp2-modified gelatinhydroxyphenylpropionic acid hydrogels reverse enhanced scleral recovery and suppress myopia development in mice.Materials today. Bio · 2025Article
- Microindentation reveals softening of the equatorial and anterior sclera during early myopia development in tree shrew eyes.Acta biomaterialia · 2025Article
- Bidirectional Phosphorylation Changes in Opsins Associated With Early Myopia and Hyperopia Signal Regulation by Phosphoproteomics.Investigative ophthalmology & visual science · 2025Article
- Biomechanical properties of the trabecular meshwork in intraocular pressure regulation: a review.International ophthalmology · 2025Review
- Studies of All-trans Retinoic Acid Transport in the Eye.Investigative ophthalmology & visual science · 2025Article
- Analysis of In Vivo Sclera Impact on the Biomechanics of Myopic Eyes.Translational vision science & technology · 2025Article
- Causal Links Between Corneal Biomechanics and Myopia: Evidence from Bidirectional Mendelian Randomization in the UK Biobank.Bioengineering (Basel, Switzerland) · 2025Article
- Modulation of All-Trans Retinoic Acid by Light and Dopamine in the Murine Eye.Investigative ophthalmology & visual science · 2025Article
- The correlation between intraocular pressure and choroidal microcirculation in patients with high myopia.International journal of medical sciences · 2025Observational
- Harnessing the potential of recombinant human BMP2: regulating scleral changes in myopic guinea pigs.Frontiers in medicine · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Lifelong Changes in the Choroidal Thickness, Refractive Status, and Ocular Dimensions in C57BL/6J Mouse.Investigative ophthalmology & visual science · 2024Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Purpose: The sclera is believed to biomechanically influence eye size, facilitating the excessive axial elongation that occurs during myopigenesis. Here, we test the hypothesis that the sclera will be remodeled and exhibit altered biomechanics in the mouse model of form-deprivation (FD) myopia, accompanied by altered retinoid concentrations, a potential signaling molecule involved in the process. Methods: Male C57 Bl/6J mice were subjected to unilateral FD (n = 44 eyes), leaving the contralateral eye untreated (contra; n = 44). Refractive error and ocular biometry were measured in vivo prior to and after 1 or 3 weeks of FD. Ex vivo measurements were made of scleral biomechanical properties (unconfined compression: n = 24), scleral sulfated glycosaminoglycan (sGAG) content (dimethylmethylene blue: n = 18, and immunohistochemistry: n = 22), and ocular all-trans retinoic acid (atRA) concentrations (retina and RPE + choroid + sclera, n = 24). Age-matched naïve controls were included for some outcomes (n = 32 eyes). Results: Significant myopia developed after 1 (-2.4 ± 1.1 diopters [D], P < 0.001) and 3 weeks of FD (-4.1 ± 0.7 D, P = 0.025; mean ± standard deviation). Scleral tensile stiffness and permeability were significantly altered during myopigenesis (stiffness = -31.4 ± 12.7%, P < 0.001, and permeability = 224.4 ± 205.5%, P < 0.001). Total scleral sGAG content was not measurably altered; however, immunohistochemistry indicated a sustained decrease in chondroitin-4-sulfate and a slower decline in dermatan sulfate. The atRA increased in the retinas of eyes form-deprived for 1 week. Conclusions: We report that biomechanics and GAG content of the mouse sclera are altered during myopigenesis. All scleral outcomes generally follow the trends found in other species and support a retina-to-sclera signaling cascade underlying mouse myopigenesis.
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