ArticleAngewandte Chemie (International ed. in English)2023
Chiral Alcohols from Alkenes and Water: Directed Evolution of a Styrene Hydratase.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
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- Enhancing the β-Oxidation-Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Unlocking the Versatility of Linalool Dehydratase Reactivity: Tunable Stereochemical Control in Olefin Formation via Organic Synthesis.ACS catalysis · 2025Article
- Regioselective Hydration of Terpenes with Cofactor-Independent Carotenoid 1,2-Hydratase.Angewandte Chemie (International ed. in English) · 2025Article
- Review
- Chiral Alcohols from Alkenes and Water: Directed Evolution of a Styrene Hydratase.Angewandte Chemie (International ed. in English) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Enantioselective synthesis of chiral alcohols through asymmetric addition of water across an unactivated alkene is a highly sought-after transformation and a big challenge in catalysis. Herein we report the identification and directed evolution of a fatty acid hydratase from Marinitoga hydrogenitolerans for the highly enantioselective hydration of styrenes to yield chiral 1-arylethanols. While directed evolution for styrene hydration was performed in the presence of heptanoic acid to mimic fatty acid binding, the engineered enzyme displayed remarkable asymmetric styrene hydration activity in the absence of the small molecule activator. The evolved styrene hydratase provided access to chiral alcohols from simple alkenes and water with high enantioselectivity (>99 : 1 e.r.) and could be applied on a preparative scale.
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