Observational studyRadiology2023
Artificial Intelligence-based CT Assessment of Bronchiectasis: The COPDGene Study.
Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium.ERJ open research · 2026Article
- A novel quantitative method for CT assessment of bronchiectasis using AI-based airway segmentation and upper limits of normal airway caliber.Respiratory research · 2026Article
- Bronchiectasis in patients with chronic obstructive pulmonary disease: AI-based CT quantification using the bronchial tapering ratio.European radiology · 2026Article
- Bronchiectasis in COPD patients: AI-based CT extent assessment.European radiology · 2026Article
- Precision diagnostics in bronchiectasis: current advances in imaging, microbiology, biomarkers, and digital health.Frontiers in medicine · 2026Review
- High Airway-To-Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in COPD.Respirology (Carlton, Vic.) · 2025Article
- Artificial Intelligence-Powered Chronic Obstructive Pulmonary Disease Detection Techniques-A Review.Diagnostics (Basel, Switzerland) · 2025Review
- Automated computed tomographic analysis of bronchial thickness and mucus plugs in bronchiectasis with asthma.ERJ open research · 2025Article
- Artificial Intelligence Unveils the Unseen: Mapping Novel Lung Patterns in Bronchiectasis via Texture Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- Eosinophils, mucus plugs and clinical outcomes: findings from two COPD cohorts.The European respiratory journal · 2024Article
- Assessing the Impact of New Technologies on Managing Chronic Respiratory Diseases.Journal of clinical medicine · 2024Review
- Automated method of bronchus and artery dimension measurement in an adult bronchiectasis population.ERJ open research · 2024Article
- Clinical significance of chronic bronchitis in different racial groups.BMC pulmonary medicine · 2024Article
- Mortality Risk in Bronchiectasis.Archivos de bronconeumologia · 2024Article
- Clinical outcomes of long-term inhaled combination therapies in patients with bronchiectasis and airflow obstruction.BMC pulmonary medicine · 2024Article
- Early user perspectives on using computer-aided detection software for interpreting chest X-ray images to enhance access and quality of care for persons with tuberculosis.BMC global and public health · 2023Review
- Automatic analysis of bronchus-artery dimensions to diagnose and monitor airways disease in cystic fibrosis.Thorax · 2023Article
- Article
- Suspected Bronchiectasis and Mortality in Adults With a History of Smoking Who Have Normal and Impaired Lung Function : A Cohort Study.Annals of internal medicine · 2023Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Alejandro A DíazFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0001-5037-2919
Pietro NardelliFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0003-4280-558X
Wei WangFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0001-7333-3701
Rubén San José EstéparFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-7095-2432
Andrew YenFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0003-3456-0375
Seth KligermanFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).
Diego J MaselliFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0001-8010-0260
Wojciech R DolliverFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0001-5274-4683
Andrew TsaoFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-0357-8153
José L OrejasFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0001-7279-9024
Stefano AlibertiFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-0090-4531
Timothy R AksamitFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-5243-5394
Kendra A YoungFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-8664-7635
Gregory L KinneyFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-5218-4986
George R WashkoFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).
Edwin K SilvermanFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-3641-3822
Raúl San José EstéparFrom the Division of Pulmonary and Critical Care Medicine (A.A.D., W.R.D., A.T., J.L.O., G.R.W.), Department of Radiology (P.N., Rubén San José Estépar, Raúl San José Estépar), Division of Sleep Medicine and Circadian Disorders (W.W.), and Channing Division of Network Medicine (E.K.S.), Brigham and Women's Hospital, Harvard Medical School, 15 Francis St, Boston, MA 02115; Department of Radiology, University of California-San Diego, San Diego, Calif (A.Y., S.K.); Division of Pulmonary Diseases and Critical Care, University of Texas-San Antonio, San Antonio, Tex (D.J.M.); Department of Biomedical Sciences, Humanitas University, Milan, Italy (S.A.); Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy (S.A.); Department of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.).ORCID 0000-0002-3677-1996
Brigham and Women's Hospital · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MThe clinical impact of pulmonary vascular remodeling in smokersR01HL116473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL, WASHKO, GEORGE R · 2013 to 2021
$5.0MClinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2MClinical Implications of Bronchiectasis in SmokersR01HL133137 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2017 to 2021
$2.9MPrognostic Markers of Emphysema ProgressionR01HL149877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2020 to 2023
$2.8MUnderstanding airway mucus dysfunction in population-based studiesR01HL164824 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2022 to 2025
$2.7MCT and CXR Phenotyping Platform for Assessing COVID-19 Susceptibility and SeverityR21LM013670 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2021 to 2022
$428kNHLBI NIH HHS R01 HL116473NHLBI NIH HHS R01 HL133137NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL149877NHLBI NIH HHS R01 HL164824NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NLM NIH HHS R21 LM013670
Abstract
Background CT is the standard method used to assess bronchiectasis. A higher airway-to-artery diameter ratio (AAR) is typically used to identify enlarged bronchi and bronchiectasis; however, current imaging methods are limited in assessing the extent of this metric in CT scans. Purpose To determine the extent of AARs using an artificial intelligence-based chest CT and assess the association of AARs with exacerbations over time. Materials and Methods In a secondary analysis of ever-smokers from the prospective, observational, multicenter COPDGene study, AARs were quantified using an artificial intelligence tool. The percentage of airways with AAR greater than 1 (a measure of airway dilatation) in each participant on chest CT scans was determined. Pulmonary exacerbations were prospectively determined through biannual follow-up (from July 2009 to September 2021). Multivariable zero-inflated regression models were used to assess the association between the percentage of airways with AAR greater than 1 and the total number of pulmonary exacerbations over follow-up. Covariates included demographics, lung function, and conventional CT parameters. Results Among 4192 participants (median age, 59 years; IQR, 52-67 years; 1878 men [45%]), 1834 had chronic obstructive pulmonary disease (COPD). During a 10-year follow-up and in adjusted models, the percentage of airways with AARs greater than 1 (quartile 4 vs 1) was associated with a higher total number of exacerbations (risk ratio [RR], 1.08; 95% CI: 1.02, 1.15;
Indexed as
Artificial IntelligenceBronchiectasisPulmonary Disease, Chronic ObstructiveTomography, Emission-ComputedAgedBronchiCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedRegression AnalysisSmokers
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