Evidence map›Paper›PMID 36511804›Full record

ArticleRadiology2023

Regional Histopathology and Prostate MRI Positivity: A Secondary Analysis of the PROMIS Trial.

Vasilis Stavrinides, Joseph M Norris, Solon Karapanagiotis, Francesco Giganti, Alistair Grey, Nick Trahearn, Alex Freeman, Aiman Haider, Lina María Carmona Echeverría, Simon R J Bott and 20 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 15 institutions in 1 country.

Vasilis StavrinidesFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0003-0011-9792
Joseph M NorrisFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Solon KarapanagiotisFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0003-4460-2073
Francesco GigantiFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0001-5218-6431
Alistair GreyFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0001-6017-8546
Nick TrahearnFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-8596-0996
Alex FreemanFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Aiman HaiderFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-7005-4245
Lina María Carmona EcheverríaFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0001-6546-8980
Simon R J BottFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0001-7171-8456
Louise C BrownFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0003-2827-6634
Nicholas Burns-CoxFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-2332-4804
Timothy J DudderidgeFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0001-6373-3613
Ahmed El-Shater BosailyFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0003-0586-0897
Maneesh GheiFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Alastair HendersonFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-3546-1099
Richard G HindleyFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-7568-1694
Richard S KaplanFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-0189-8348
Robert OldroydFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-4969-3544
Chris ParkerFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0001-6512-124X
Raj PersadFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-9121-0550
Derek J RosarioFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-9086-3592
Iqbal S ShergillFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Mathias WinklerFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Alex KirkhamFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Shonit PunwaniFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
Hayley C WhitakerFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0002-2695-0202
Hashim U Ahmed *From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0003-1674-6723
Mark Emberton *From the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).ORCID 0000-0003-4230-0338
PROMIS GroupFrom the Division of Surgery and Interventional Science (V.S., J.M.N., F.G., A.G., L.M.C.E., S.P., H.C.W., M.E.), Medical Research Council Clinical Trials Unit (L.C.B., R.S.K.), and Centre for Medical Imaging (S.P.), University College London, Charles Bell House, 43-45 Foley St, London W1W 7TS, UK; The Alan Turing Institute, London, UK (V.S., S.K.); Departments of Urology (V.S., J.M.N., A.G., M.E.), Radiology (F.G., A.K., S.P.), and Pathology (A.F., A. Haider., L.M.C.E.), University College London Hospitals NHS Foundation Trust, London, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK (S.K.); Computational Pathology Group, Institute of Cancer Research, Sutton, London, UK (N.T.); Department of Urology, Frimley Health NHS Foundation Trust, London, UK (S.R.J.B.); Department of Urology, Taunton & Somerset NHS Foundation Trust, Taunton, UK (N.B.C.); Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK (T.J.D.); Department of Radiology, Royal Free London NHS Foundation Trust, London, UK (A.E.S.B.); Department of Urology, Whittington Health NHS Trust, London, UK (M.G.); Department of Urology, Maidstone & Tunbridge Wells NHS Trust, Tunbridge Wells, UK (A. Henderson); Department of Urology, Hampshire Hospitals NHS Foundation Trust, UK (R.G.H.); Public and patient representative, Nottingham, UK (R.O.); Department of Academic Urology, The Royal Marsden NHS Foundation Trust, Sutton, UK (C.P.); Department of Urology, North Bristol NHS Trust, Bristol, UK (R.P.); Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (D.J.R.); Department of Urology, Wrexham Maelor Hospital NHS Trust, Wrexham, UK (I.S.S.); Department of Urology, Imperial College Healthcare NHS Trust, London, UK (M.W., H.U.A.); and Imperial Prostate, Division of Surgery, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, London, UK (M.W., H.U.A.).
University College London Hospitals NHS Foundation Trust · GBUniversity College London · GBImperial College Healthcare NHS Trust · GBFrimley Health NHS Foundation Trust · GBHampshire Hospitals NHS Foundation Trust · GBInstitute of Cancer Research · GBMaidstone and Tunbridge Wells NHS Trust · GBNorth Bristol NHS Trust · GBRoyal Free London NHS Foundation Trust · GBRoyal Marsden NHS Foundation Trust · GBSheffield Teaching Hospitals NHS Foundation Trust · GBTaunton & Somerset NHS Foundation Trust · GBUniversity Hospital Southampton NHS Foundation Trust · GBWhittington Health NHS Trust · GBWrexham Maelor Hospital · GB

Funding

Department of Health 09/22/67Medical Research Council MC_UU_00004/02Medical Research Council MC_UU_12023/20Medical Research Council MC_UU_12023/28Medical Research Council MR/R014043/1Medical Research Council MR/S005897/1Medical Research Council MR/S00680X/1Prostate Cancer UK PG10-17
6 · The paper itself

Abstract

Background The effects of regional histopathologic changes on prostate MRI scans have not been accurately quantified in men with an elevated prostate-specific antigen (PSA) level and no previous biopsy. Purpose To assess how Gleason grade, maximum cancer core length (MCCL), inflammation, prostatic intraepithelial neoplasia (PIN), or atypical small acinar proliferation within a Barzell zone affects the odds of MRI visibility. Materials and Methods In this secondary analysis of the Prostate MRI Imaging Study (PROMIS; May 2012 to November 2015), consecutive participants who underwent multiparametric MRI followed by a combined biopsy, including 5-mm transperineal mapping (TPM), were evaluated. TPM pathologic findings were reported at the whole-prostate level and for each of 20 Barzell zones per prostate. An expert panel blinded to the pathologic findings reviewed MRI scans and declared which Barzell areas spanned Likert score 3-5 lesions. The relationship of Gleason grade and MCCL to zonal MRI outcome (visible vs nonvisible) was assessed using generalized linear mixed-effects models with random intercepts for individual participants. Inflammation, PIN, and atypical small acinar proliferation were similarly assessed in men who had negative TPM results. Results Overall, 161 men (median age, 62 years [IQR, 11 years]) were evaluated and 3179 Barzell zones were assigned MRI status. Compared with benign areas, the odds of MRI visibility were higher when a zone contained cancer with a Gleason score of 3+4 (odds ratio [OR], 3.1; 95% CI: 1.9, 4.9;

Indexed as

Prostatic Intraepithelial NeoplasiaProstatic NeoplasmsHumansImage-Guided BiopsyInflammationMagnetic Resonance ImagingMaleMiddle AgedNeoplasm GradingProstate

Identifiers

PMID36511804
PMCPMC7614676
OpenAlexW4311243224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.