Evidence map›Paper›PMID 36511712›Full record

ArticleMicrobiology spectrum2023

Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions.

Preeti Garai, John M Atack, Brandon M Wills, Michael P Jennings, Lauren O Bakaletz, Kenneth L Brockman

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. [Research progress on epithelial mucosal barrier impairment contributing to chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Interaction ofFrontiers in cellular and infection microbiology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Preeti GaraiDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
John M AtackInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.ORCID 0000-0002-7994-6995
Brandon M WillsDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Michael P JenningsInstitute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.ORCID 0000-0002-1027-4684
Lauren O BakaletzAbigail Wexner Research Institute, Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0002-0017-1710
Kenneth L BrockmanDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-0339-7504
Medical College of Wisconsin · USGriffith University · AUNationwide Children's Hospital · US

Funding

Otitis media: role of epigenetic regulation on NTHI pathogenesis and optimal vaccine designR01DC015688 · NIDCD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BAKALETZ, LAUREN O, JENNINGS, MICHAEL PAUL · 2016 to 2020
$2.2M
Role of epigenetic regulation in the persistence of NTHI during colonization, ascension of the Eustachian tube and chronic otitis mediaR21DC016709 · NIDCD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BROCKMAN, KENNETH L · 2017 to 2019
$455k
NIDCD NIH HHS R01 DC015688NIDCD NIH HHS R21 DC016709
6 · The paper itself

Abstract

Adherence of nontypeable Haemophilus influenzae (NTHi) to the host airway is an essential initial step for asymptomatic colonization of the nasopharynx, as well as development of disease. NTHi relies on strict regulation of multiple adhesins for adherence to host substrates encountered in the airway. NTHi encode a phase-variable cytoplasmic DNA methyltransferase, ModA, that regulates expression of multiple genes; a phasevarion (phase-variable regulon). Multiple

Indexed as

Haemophilus influenzaePhase VariationAdhesins, BacterialHumansLungNasopharynxAdhesins, BacterialadherenceModA phasevarionNTHirespiratory tract substrates

Identifiers

PMID36511712
PMCPMC9927368
OpenAlexW4311243799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.