Evidence map›Paper›PMID 36511710›Full record

ArticleMicrobiology spectrum2023

HIV-Positive Patients on Antiretroviral Therapy Have an Altered Mucosal Intestinal but Not Oral Microbiome.

Jingjing Meng, Junyi Tao, Yaa Abu, Daniel Andrew Sussman, Mohit Girotra, Dido Franceschi, Sabita Roy

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jingjing Meng *Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.
Junyi Tao *Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.ORCID 0000-0003-2638-5386
Yaa AbuDepartment of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.ORCID 0000-0001-7285-0117
Daniel Andrew SussmanDepartment of Gastroenterology, University of Miami Medical Group, Miami, Florida, USA.
Mohit GirotraDepartment of Gastroenterology, University of Miami Medical Group, Miami, Florida, USA.
Dido FranceschiDepartment of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.
Sabita RoyDepartment of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.ORCID 0000-0002-6192-8289
University of Miami · US

Funding

Medical Scientist Training ProgramT32GM145462 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALESSIA FORNONI, Daniel Jon Liebl · 2022 to 2026
$3.9M
Role of Microbial dysbiosis and altered metabolomics in the context of Opioid abuse and ART in HIV disease progressionR01DA043252 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2017 to 2021
$3.0M
Microbial Dysbiosis and TLR2 Activation Contribute to Immune Activation, Inflammation and HIV Persistence in the Context of Opioid Abuse Despite ART TherapyR01DA044582 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2017 to 2021
$2.6M
Role of Gut Microbiome- Brain Axis in Modulating CNS Inflammasomes in the Neuropathology Produced by Opioid Exposure and HIV R01DA050542 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2019 to 2023
$2.5M
Role of Gut Microbiome in HIV/Opioid Induced Peripheral NeuropathyR01DA047089 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN, RAMAKRISHNAN, SUNDARAM · 2018 to 2022
$2.3M
Prenatal Opioid Exposure and Inflammation: The Role of the Microbiome and Epigenome.F31DA053795 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ABU, YAA · 2022 to 2024
$158k
NIDA NIH HHS F31 DA053795NIDA NIH HHS R01 DA043252NIDA NIH HHS R01 DA044582NIDA NIH HHS R01 DA047089NIDA NIH HHS R01 DA050542
6 · The paper itself

Abstract

This study characterized compositional and functional shifts in the intestinal and oral microbiome in HIV-positive patients on antiretroviral therapy compared to HIV-negative individuals. Seventy-nine specimens were collected from 5 HIV-positive and 12 control subjects from five locations (colon brush, colon wash, terminal ileum [TI] brush, TI wash, and saliva) during colonoscopy and at patient visits. Microbiome composition was characterized using 16S rRNA sequencing, and microbiome function was predicted using bioinformatics tools (PICRUSt and BugBase). Our analysis indicated that the β-diversity of all intestinal samples (colon brush, colon wash, TI brush, and TI wash) from patients with HIV was significantly different from patients without HIV. Specifically, bacteria from genera

Indexed as

Gastrointestinal MicrobiomeHIV InfectionsMicrobiotaBacteriaHumansIntestinal MucosaRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S RNAantiretroviral therapyHIVhuman microbiomeintestinal microbiomeoral microbiome

Identifiers

PMID36511710
PMCPMC9927552
OpenAlexW4311284124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.