Evidence map›Paper›PMID 36511702›Full record

ArticleInfection and immunity2023

Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice.

Georgy Popov, Aline Fiebig-Comyn, Lukas Syriste, Dustin J Little, Tatiana Skarina, Peter J Stogios, Sarah Birstonas, Brian K Coombes, Alexei Savchenko

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  5. Modulation ofmBio · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Georgy PopovDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-7585-9237
Aline Fiebig-ComynDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Lukas SyristeDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Dustin J LittleDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-7084-8141
Tatiana SkarinaDepartment of Chemical Engineering and Applied Chemistry, Toronto University, Toronto, Ontario, Canada.
Peter J StogiosDepartment of Chemical Engineering and Applied Chemistry, Toronto University, Toronto, Ontario, Canada.
Sarah BirstonasDepartment of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada.
Brian K CoombesDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-9883-1010
Alexei SavchenkoDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-5256-9237
University of Calgary · CAMcMaster University · CAToronto Metropolitan University · CAUniversity of Toronto · CA

Funding

NIAID NIH HHS HHSN272201700060C
6 · The paper itself

Abstract

The NleGs are the largest family of type 3 secreted effectors in attaching and effacing (A/E) pathogens, such as enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli, and Citrobacter rodentium. NleG effectors contain a conserved C-terminal U-box domain acting as a ubiquitin protein ligase and target host proteins via a variable N-terminal portion. The specific roles of these effectors during infection remain uncertain. Here, we demonstrate that the three NleG effectors-NleG1

Indexed as

Enterobacteriaceae InfectionsEnterohemorrhagic Escherichia coliEnteropathogenic Escherichia coliEscherichia coli ProteinsAdaptor Proteins, Signal TransducingAnimalsBiological TransportCitrobacter rodentiumGolgi Matrix ProteinsHumansMiceAdaptor Proteins, Signal TransducingEscherichia coli ProteinsGolgi Matrix ProteinsGopc protein, mouseCitrobacter rodentium infection modeleffectorsNleGtype 3 secretion system

Identifiers

PMID36511702
PMCPMC9872709
OpenAlexW4311283728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.