ArticleStroke2023
Risk Factors and Causes of Ischemic Stroke in 1322 Young Adults.
Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Return to Work After Ischemic Stroke in Young Adults: A Multicenter Cohort Study, Systematic Review, and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Stroke in the Young: Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study.Neurology · 2026Article
- Association Between Recent Mechanical Risk Factors for Venous Thrombosis and Young-Onset Cryptogenic Ischemic Stroke.Stroke · 2026Article
- Antithrombotic Therapy and Bleeding Risk Among Young Adults After Ischemic Stroke.JAMA network open · 2026Observational
- Estimated pulse wave velocity predicts outcomes after acute ischemic stroke: a multinational cohort analysis.American journal of hypertension · 2026Article
- Demographics, risk factor profiles and etiologies in young ischemic and hemorrhagic stroke - the United Kingdom Young Stroke Study (UKYSS).Journal of neurology · 2026Observational
- Lactylation of GDF15 Regulates Angiogenesis in Ischemic Stroke via Activating PI3K/AKT/mTOR Pathway.Molecular neurobiology · 2026Article
- Diagnostic Yield of Comprehensive Etiologic Evaluation in Young Adults with Ischemic Stroke: Toward a Phenotype-Driven Approach.Journal of clinical medicine · 2026Article
- Article
- Assessing Outcome of tPA Therapy in Patients with Acute Ischemic Stroke (0-three hours).Pakistan journal of medical sciences · 2026Article
- Graves' disease-related reversible intracranial arteriopathy presenting with ischemic stroke: A case report and literature review.Medicine · 2026Review
- Cardiac Organ Damage in Young Adults with Cryptogenic Ischaemic Stroke: The SECRETO Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Article
- Article
- Preceding Infections and Coagulation Biomarkers in Early-Onset Cryptogenic Ischemic Stroke.Stroke · 2026Observational
- Association of factor V leiden and ischemic stroke in young adults: a national inpatient sample analysis.Journal of thrombosis and thrombolysis · 2026Article
- Article
- Arterial ischaemic stroke in adolescents and very young adults-results of a European cohort.European stroke journal · 2026Article
- Epidemiological and Clinical Profile of Acute Stroke in Young Adults from a Tertiary Stroke Center in Abu Dhabi-A Retrospective Study.Journal of clinical medicine · 2026Article
- PM 2.5 and black carbon associated with acute ischaemic stroke: an ecological study.BMJ neurology open · 2026Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 16 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentification of risk factors and causes of stroke is key to optimize treatment and prevent recurrence. Up to one-third of young patients with stroke have a cryptogenic stroke according to current classification systems (Trial of ORG 10172 in Acute Stroke Treatment [TOAST] and atherosclerosis, small vessel disease, cardiac pathology, other causes, dissection [ASCOD]). The aim was to identify risk factors and leads for (new) causes of cryptogenic ischemic stroke in young adults, using the pediatric classification system from the IPSS study (International Pediatric Stroke Study).
methodsThis is a multicenter prospective cohort study conducted in 17 hospitals in the Netherlands, consisting of 1322 patients aged 18 to 49 years with first-ever, imaging confirmed, ischemic stroke between 2013 and 2021. The main outcome was distribution of risk factors according to IPSS classification in patients with cryptogenic and noncryptogenic stroke according to the TOAST and ASCOD classification.
resultsThe median age was 44.2 years, and 697 (52.7%) were men. Of these 1322 patients, 333 (25.2%) had a cryptogenic stroke according to the TOAST classification. Additional classification using the ASCOD criteria reduced the number patients with cryptogenic stroke from 333 to 260 (19.7%). When risk factors according to the IPSS were taken into account, the number of patients with no potential cause or risk factor for stroke reduced to 10 (0.8%).
conclusionsAmong young adults aged 18 to 49 years with a cryptogenic ischemic stroke according to the TOAST classification, risk factors for stroke are highly prevalent. Using a pediatric classification system provides new leads for the possible causes in cryptogenic stroke, and could potentially lead to more tailored treatment for young individuals with stroke.
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