Evidence map›Paper›PMID 36511102›Full record

ReviewClinical science (London, England : 1979)2022

Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs).

Toluwalase Awoyemi, Ana Sofia Cerdeira, Wei Zhang, Shuhan Jiang, Maryam Rahbar, Prassana Logenthiran, Christopher Redman, Manu Vatish

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical science (London, England : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Exosomal-complement system activation in preeclampsia.The journal of obstetrics and gynaecology research · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Endogenous retrovirus HERVH-derived lncRNAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Toluwalase AwoyemiNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.ORCID 0000-0003-1542-9435
Ana Sofia CerdeiraNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
Wei ZhangNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
Shuhan JiangNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
Maryam RahbarNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
Prassana LogenthiranNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
Christopher RedmanNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
Manu VatishNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, U.K.
University of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia (PE) is a hypertensive complication of pregnancy that affects 2-8% of women worldwide and is one of the leading causes of maternal deaths and premature birth. PE can occur early in pregnancy (<34 weeks gestation) or late in pregnancy (>34 weeks gestation). Whilst the placenta is clearly implicated in early onset PE (EOPE), late onset PE (LOPE) is less clear with some believing the disease is entirely maternal whilst others believe that there is an interplay between maternal systems and the placenta. In both types of PE, the syncytiotrophoblast (STB), the layer of the placenta in direct contact with maternal blood, is stressed. In EOPE, the STB is oxidatively stressed in early pregnancy (leading to PE later in gestation- the two-stage model) whilst in LOPE the STB is stressed because of villous overcrowding and senescence later in pregnancy. It is this stress that perturbs maternal systems leading to the clinical manifestations of PE. Whilst some of the molecular species driving this stress have been identified, none completely explain the multisystem nature of PE. Syncytiotrophoblast membrane vesicles (STB-EVs) are a potential contributor to this multisystem disorder. STB-EVs are released into the maternal circulation in increasing amounts with advancing gestational age, and this release is further exacerbated with stress. There are good in vitro evidence that STB-EVs are taken up by macrophages and liver cells with additional evidence supporting endothelial cell uptake. STB-EV targeting remains in the early stages of discovery. In this review, we highlight the role of STB-EVs in PE. In relation to current research, we discuss different protocols for ex vivo isolation of STB-EVs, as well as specific issues involving tissue preparation, isolation (some of which may be unique to STB-EVs), and methods for their analysis. We suggest potential solutions for these challenges.

Indexed as

Extracellular VesiclesPre-EclampsiaFemaleGestational AgeHumansPlacentaPregnancyTrophoblastsExtracellular vesiclesnanoparticlesPlacentaPreeclampsiaSTB-EVssyncytiotrophoblast

Identifiers

PMID36511102
PMCPMC9751756
OpenAlexW4311390137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.