Evidence map›Paper›PMID 36510775›Full record

ArticleGut and liver2023

The Expression of Programmed Death-Ligand 1 on Immune Cells Is Related to a Better Prognosis in Biliary Tract Cancer.

Sung Chan Kwon, Seungmin Bang, Young Nyun Park, Ji Hoon Park, So Jeong Kim, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song and 2 more

Open access · diamondAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut and liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sung Chan KwonDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0002-6838-2258
Seungmin BangDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0001-5209-8351
Young Nyun ParkDepartment of Pathology, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0003-0357-7967
Ji Hoon ParkDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0003-3083-6856
So Jeong KimDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0003-0157-0112
Jung Hyun JoDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0002-2641-8873
Moon Jae ChungDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0002-5920-8549
Jeong Youp ParkDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0003-0110-8606
Seung Woo ParkDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0001-8230-964X
Si Young SongDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0002-1417-4314
Eunhyang ParkDepartment of Pathology, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0003-2658-5054
Hee Seung LeeDepartment of Internal Medicine, Institute of Gastroenterology, Seoul, Korea.ORCID 0000-0002-2825-3160
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Programmed death-ligand 1 (PD-L1) expression in tumor cells is associated with a poor biliary tract cancer (BTC) prognosis; tumor-infiltrating immune cells in the tumor microenvironment are associated with a better prognosis. The effect of PD-L1 expression on immune cells on survival is unclear. We investigated the relationship between PD-L1 expression in immune cells and BTC prognosis. Methods: PD-L1 expression was evaluated using an anti-PD-L1 22C3 mouse monoclonal primary antibody, and its relationships with clinical characteristics and prognosis were analyzed using the Cox proportional hazard model to investigate the prognostic performance of PD-L1 in BTC. Results: Among 144 analyzed cases, patients with positive PD-L1 expression in tumor cells and negative PD-L1 expression in immune cells showed poorer overall survival rates than those exhibiting other expressions (tumor cells: hazard ratio [HR]=1.023, p<0.001; immune cells: HR=0.983, p=0.021). PD-L1 expression in tumor cells was an independent predictor of poor overall survival (HR=1.024, p<0.001). In contrast, PD-L1 expression in immune cells was a predictive marker of good prognosis (HR=0.983, p=0.018). Conclusions: PD-L1 expression in immune cells may be used as an independent factor to evaluate the prognosis of patients with BTC.

Indexed as

B7-H1 AntigenBiliary Tract NeoplasmsAnimalsHumansMicePrognosisTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanBiliary tract neoplasmsPrognosisSurvival

Identifiers

PMID36510775
PMCPMC10651371
OpenAlexW4311282616

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.