Evidence map›Paper›PMID 36510413›Full record

ArticleNeuroImage. Clinical2022

Reward-based decision-making in mesial temporal lobe epilepsy patients with unilateral hippocampal sclerosis pre- and post-surgery.

Adrià Vilà-Balló, Myriam De la Cruz-Puebla, Diana López-Barroso, Júlia Miró, Jacint Sala-Padró, David Cucurell, Mercè Falip, Antoni Rodríguez-Fornells

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Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Management of anhedonia after epilepsy surgery.Epilepsy & behavior reports · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adrià Vilà-BallóDepartment of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain.; Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain; Department of Psychology, Faculty of Education and Psychology, University of Girona, Girona, Spain. Electronic address: adriavila@ub.edu.
Myriam De la Cruz-PueblaCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology, and Immunology, Neurosciences Institute, Autonomous University of Barcelona, Barcelona, Spain; Department of Equity in Brain Health, Global Brain Health Institute (GBHI), University of California, San Francisco (UCSF), CA, USA; Department of Internal Medicine, Health Sciences Faculty, Technical University of Ambato, Tungurahua, Ecuador; Dept. of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology, University of Málaga, Málaga, Spain.
Diana López-BarrosoCognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Málaga, Málaga, Spain; Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain; Dept. of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology, University of Málaga, Málaga, Spain.
Júlia MiróCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain.; Epilepsy Unit, Neurological Service, Neurology and Genetics Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Jacint Sala-PadróCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain.; Dept. of Psychobiology and Methodology of Behavioural Sciences, Faculty of Psychology, University of Málaga, Málaga, Spain.
David CucurellDepartment of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Mercè FalipEpilepsy Unit, Neurological Service, Neurology and Genetics Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Antoni Rodríguez-FornellsDepartment of Cognition, Development and Educational Psychology, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCorrect functioning of the reward processing system is critical for optimizing decision-making as well as preventing the development of addictions and/or neuropsychiatric symptoms such as depression, apathy, and anhedonia. Consequently, patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis (mTLE-UHS) represent an excellent opportunity to study the brain networks involved in this system.

objectiveThe aim of the current study was to evaluate decision-making and the electrophysiological correlates of feedback processing in a sample of mTLE-UHS patients, compared to healthy controls. In addition, we assessed the impact of mesial temporal lobe surgical resection on these processes, as well as general, neuropsychological functioning.

method17 mTLE-UHS patients and 17 matched healthy controls completed: [1] a computerized version of the Game of Dice Task, [2] a Standard Iowa Gambling Task, and [3] a modified ERP version of a probabilistic gambling task coupled with multichannel electroencephalography. Neuropsychological scores were also obtained both pre- and post-surgery.

resultsBehavioral analyses showed a pattern of increased risk for the mTLE-UHS group in decision-making under ambiguity compared to the control group. A decrease in the amplitude of the Feedback Related Negativity (FRN), a weaker effect of valence on delta power, and a general reduction of delta and theta power in the mTLE-UHS group, as compared to the control group, were also found. The beta-gamma activity associated with the delivery of positive reward was similar in both groups. Behavioral performance and electrophysiological measures did not worsen post-surgery.

conclusionsPatients with mTLE-UHS showed impairments in decision-making under ambiguity, particularly when they had to make decisions based on the outcomes of their choices, but not in decision-making under risk. No group differences were observed in decision-making when feedbacks were random. These results might be explained by the abnormal feedback processing seen in the EEG activity of patients with mTLE-UHS, and by concomitant impairments in working memory, and memory. These impairments may be linked to the disruption of mesial temporal lobe networks. Finally, feedback processing and decision-making under ambiguity were already affected in mTLE-UHS patients pre-surgery and did not show evidence of clear worsening post-surgery.

Indexed as

Epilepsy, Temporal LobeHippocampal SclerosisElectroencephalographyHippocampusHumansMagnetic Resonance ImagingSclerosisTemporal LobeDecision-makingEvent-related oscillations (EROs)Event-related potentials (ERP)Mesial temporal lobe epilepsyReward processingUnilateral hippocampal sclerosis

Identifiers

PMID36510413
PMCPMC9668642

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.