Evidence map›Paper›PMID 36510334›Full record

ArticleActa neuropathologica communications2022

Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study.

Anna Raunio, Ville Kivistö, Mia Kero, Jarno Tuimala, Sara Savola, Minna Oinas, Eloise Kok, Kia Colangelo, Anders Paetau, Tuomo Polvikoski and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Anna RaunioDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Ville KivistöDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Mia KeroDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Jarno TuimalaDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Sara SavolaDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Minna OinasDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Eloise KokDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Kia ColangeloDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Anders PaetauDepartment of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Tuomo PolvikoskiNewcastle University Translational and Clinical Research Institute, University of Newcastle, Newcastle Upon Tyne, UK.
Pentti J TienariTranslational Immunology, Research Programs Unit, University of Helsinki, Helsinki, Finland.
Henri Puttonen *Department of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland.
Liisa Myllykangas *Department of Pathology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014, Helsinki, Finland. liisa.myllykangas@helsinki.fi.ORCID 0000-0002-2237-5466
University of Helsinki · FINewcastle University · GBUniversity Hospital of North Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation of spinal cord and peripheral LRP can elucidate mechanisms of Lewy body disorders and origins of synuclein accumulation. Still, very few unselected studies have focused on LRP in these regions. Here we analysed LRP in spinal cord, dorsal root ganglion, and adrenal gland in the population-based Vantaa 85 + study, including every ≥ 85 years old citizen living in the city of Vantaa in 1991 (n = 601). Samples from spinal cord (C6-7, TH3-4, L3-4, S1-2) were available from 303, lumbar dorsal root ganglion from 219, and adrenal gland from 164 subjects. Semiquantitative scores of LRP were determined from immunohistochemically stained sections (anti-alpha-synuclein antibody 5G4). LRP in the ventral and dorsal horns of spinal cord, thoracic intermediolateral column, dorsal root ganglion and adrenal gland were compared with brain LRP, previously determined according to DLB Consortium criteria and by caudo-rostral versus amygdala-based LRP classification. Spinal LRP was found in 28% of the total population and in 61% of those who had LRP in the brain. Spinal cord LRP was found only in those subjects with LRP in the brain, and the quantity of spinal cord LRP was associated with the severity of brain LRP (p < 0.001). Unsupervised K-means analysis identified two cluster types of spinal and brain LRP corresponding to caudo-rostral and amygdala-based LRP types. The caudo-rostral LRP type exhibited more frequent and severe pathology in spinal cord, dorsal root ganglion and adrenal gland than the amygdala-based LRP type. Analysis of specific spinal cord regions showed that thoracic intermediolateral column and sacral dorsal horn were the most frequently affected regions in both LRP types. This population-based study on brain, spinal and peripheral LRP provides support to the concept of at least two distinct LRP types.

Indexed as

Lewy Body DiseaseAged, 80 and overAmygdalaAnimalsBrainGanglia, SpinalHumansSpinal CordAdrenal glandAged, 80 and overAlpha-SynucleinDorsal root ganglionLewy body diseaseNeuropathologySpinal cord

Identifiers

PMID36510334
PMCPMC9743559
OpenAlexW4311127558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.