Evidence map›Paper›PMID 36510302›Full record

SynthesisSystematic reviews2022

Management of symptomatic cholelithiasis: a systematic review.

Rivfka Shenoy, Patrick Kirkland, Joseph E Hadaya, M Wynn Tranfield, Michael DeVirgilio, Marcia M Russell, Melinda Maggard-Gibbons

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rivfka ShenoyDepartment of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. rivfkashenoy@mednet.ucla.edu.ORCID 0000-0002-0789-7944
Patrick KirklandDepartment of Surgery, Los Angeles County Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Joseph E HadayaDepartment of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
M Wynn TranfieldLouise M. Darling Biomedical Library, UCLA Library, University of California, Los Angeles, CA, USA.
Michael DeVirgilioDepartment of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Marcia M RussellDepartment of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Melinda Maggard-GibbonsDepartment of Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSymptomatic cholelithiasis is a common surgical disease and accounts for half of the over one million cholecystectomies performed in the USA annually. Despite its prevalence, only one prior systematic review has examined the evidence around treatment strategies and it contained a narrow scope. The goal of this systematic review was to analyze the clinical effectiveness of treatment options for symptomatic cholelithiasis, including surgery, non-surgical therapies, and ED pain management strategies.

methodsLiterature search was performed from January 2000 through June 2020, and a narrative analysis was performed as studies were heterogeneous.

resultsWe identified 12 publications reporting on 10 trials (9 randomized controlled trials and 1 observational study) comparing treatment methods. The studies assessed surgery, observation, lithotripsy, ursodeoxycholic acid, electro-acupuncture, and pain-management strategies in the emergency department. Only one compared surgery to observation.

conclusionThis work presents the existing data and underscores the current gap in knowledge regarding treatment for patients with symptomatic cholelithiasis. We use these results to suggest how future trials may guide comparisons between the timing of surgery and watchful waiting to create a set of standardized guidelines. Providing appropriate and timely treatment for symptomatic cholelithiasis is important to streamline care for a costly and prevalent disease.

trial registrationPROSPERO Protocol Number: CRD42020153153.

Indexed as

CholelithiasisEmergency Service, HospitalHumansObservational Studies as TopicPrevalenceTreatment Outcomebiliary coliccholecystectomymanagementSymptomatic cholelithiasistreatmentUDCA

Identifiers

PMID36510302
PMCPMC9743645

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.