Evidence map›Paper›PMID 36510233›Full record

Trial reportTrials2022

Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial.

Linda Kwakkenbos, Marie-Eve Carrier, Joep Welling, Brooke Levis, Alexander W Levis, Maureen Sauve, Kimberly A Turner, Lydia Tao, Kylene Aguila, Andrea Carboni-Jiménez and 11 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419208 (Randomized Controlled Trial of the Scleroderma Patient-centered Intervention Network Hand Exercise Program), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419208 nacompletednot on this map

Randomized Controlled Trial of the Scleroderma Patient-centered Intervention Network Hand Exercise Program

TypeinterventionalSponsorLady Davis InstituteRan2018 to 2020Enrolled466ConditionsScleroderma, Systemic SclerosisArmsSPIN-HAND Program
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 5 countries.

Linda KwakkenbosClinical Psychology, Radboud University, Nijmegen, The Netherlands.
Marie-Eve CarrierLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Joep WellingNVLE Dutch Patient Organization for Systemic Autoimmune Diseases, Utrecht, The Netherlands.
Brooke LevisLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Alexander W LevisDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Cambridge, MA, USA.
Maureen SauveScleroderma Society of Ontario, Hamilton, ON, Canada.
Kimberly A TurnerLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Lydia TaoLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Kylene AguilaLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Andrea Carboni-JiménezLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Mara Cañedo-AyalaLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Sami HarbLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Cornelia van den EndeSint Maartenskliniek, Nijmegen, The Netherlands.
Marie HudsonLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada.
Ward van BredaFaculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands.
Christelle NguyenUniversité Paris Descartes, Université de Paris, Paris, France.
Isabelle BoutronUniversité Paris Descartes, Université de Paris, Paris, France.
François RannouUniversité Paris Descartes, Université de Paris, Paris, France.
Brett D ThombsLady Davis Institute for Medical Research of the Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC, H3T 1E2, Canada. brett.thombs@mcgill.ca.ORCID http://orcid.org/0000-0002-5644-8432
Luc MouthonUniversité Paris Descartes, Université de Paris, Paris, France.
SPIN Investigators
Jewish General Hospital · CADélégation Paris 5 · FRHarvard University · USMcGill University Health Centre · CAMultiple Sclerosis Society of Canada · CARadboud University Nijmegen · NLSint Maartenskliniek · NLVrije Universiteit Amsterdam · NL

Funding

CIHR PJT-149073
6 · The paper itself

Abstract

backgroundSystemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. Functional impairment of hands is common. The Scleroderma Patient-centered Intervention Network (SPIN)-HAND trial compared effects of offering access to an online self-guided hand exercise program to usual care on hand function (primary) and functional health outcomes (secondary) in people with SSc with at least mild hand function limitations.

methodsThe pragmatic, two-arm, parallel-group cohort multiple randomized controlled trial was embedded in the SPIN Cohort. Cohort participants with Cochin Hand Function Scale (CHFS) scores ≥ 3 and who indicated interest in using the SPIN-HAND Program were randomized (3:2 ratio) to an offer of program access or to usual care (targeted N = 586). The SPIN-HAND program consists of 4 modules that address (1) thumb flexibility and strength; (2) finger bending; (3) finger extension; and (4) wrist flexibility and strength. The primary outcome analysis compared CHFS scores 3 months post-randomization between participants offered versus not offered the program. Secondary outcomes were CHFS scores 6 months post-randomization and functional health outcomes (Patient-Reported Outcomes Measurement Information System profile version 2.0 domain scores) 3 and 6 months post-randomization.

resultsIn total, 466 participants were randomized to intervention offer (N = 280) or usual care (N = 186). Of 280 participants offered the intervention, 170 (61%) consented to access the program. Of these, 117 (69%) viewed at least one hand exercise instruction video and 77 (45%) logged into the program website at least 3 times. In intent-to-treat analyses, CHFS scores were 1.2 points lower (95% CI - 2.8 to 0.3) for intervention compared to usual care 3 months post-randomization and 0.1 points lower (95% CI - 1.8 to 1.6 points) 6 months post-randomization. There were no statistically significant differences in other outcomes.

conclusionThe offer to use the SPIN-HAND Program did not improve hand function. Low offer uptake, program access, and minimal usage among those who accessed the program limited our ability to determine if using the program would improve function. To improve engagement, the program could be tested in a group format or as a resource to support care provided by a physical or occupational therapist.

trial registrationNCT03419208 . Registered on February 1, 2018.

Indexed as

Scleroderma, SystemicExercise TherapyHumansPatient-Centered CareUpper ExtremityCohort multiple RCTOccupational therapyPhysical therapyRandomized controlled trialScleroderma, SystemicSystemic sclerosisTele-rehabilitation

Identifiers

PMID36510233
PMCPMC9742661
OpenAlexW4311575664

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.