Evidence map›Paper›PMID 36510002›Full record

ArticleGene therapy2023

An ectopic enhancer restores CFTR expression through de novo chromatin looping.

Jenny L Kerschner, Alekh Paranjapye, Nirbhayaditya Vaghela, Michael D Wilson, Ann Harris

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Cellular heterogeneity in the 16HBE14oPhysiological reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jenny L KerschnerDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44116, USA.ORCID 0000-0002-1980-2543
Alekh ParanjapyeDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44116, USA.
Nirbhayaditya VaghelaDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44116, USA.
Michael D WilsonDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44116, USA.
Ann HarrisDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44116, USA. ann.harris@case.edu.ORCID 0000-0002-6541-2546
Case Western Reserve University · US

Funding

Tissue-specific regulation of a gene essential for normal airway epitheliaR01HL094585 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI HARRIS, ANN · 2009 to 2020
$2.9M
Transcriptional Networks Regulating Luminal Environment in the EpididymisR01HD068901 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI HARRIS, ANN · 2011 to 2023
$2.8M
NHLBI NIH HHS R01 HL094585NICHD NIH HHS R01 HD068901
6 · The paper itself

Abstract

Transcription of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is regulated by both ubiquitous and cell-type selective cis-regulatory elements (CREs). These CREs include extragenic and intronic enhancers that bind lineage-specific transcription factors, and architectural protein-marked structural elements. Deletion of the airway-selective -35 kb enhancer in 16HBE14o

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorEnhancer Elements, GeneticChromatinPromoter Regions, GeneticTranscription FactorsChromatinCystic Fibrosis Transmembrane Conductance RegulatorTranscription Factors

Identifiers

PMID36510002
PMCPMC11227122
OpenAlexW4311130928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.