ArticleAdvanced materials (Deerfield Beach, Fla.)2023
Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology.
Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Formation of Hybrid Spherical Silica Particles Using a Novel Alkoxy-Functional Polysilsesquioxane Macromonomer as a Precursor in an Acid-Catalyzed Sol-Gel Process.Materials (Basel, Switzerland) · 2025Article
- R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules.The journal of physical chemistry letters · 2025Article
- Exploiting Silica-Binding and Silica-Forming Proteins as Versatile Tools for One-Step Enzyme Immobilization on Siliceous Materials.International journal of molecular sciences · 2025Review
- The structure of His15 acetamide-modified hen egg-white lysozyme: a nice surprise from an old friend.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Molecular-Level Design Principles and Strategies of Peptide Self-Assembly Nanomaterials: From Sequence Engineering to Functional Applications.International journal of nanomedicine · 2025Review
- A pH-Dependent Phase Separation Drives Polyamine-Mediated Silicification from Undersaturated Solutions.ACS nano · 2024Article
- Understanding Biomineralization Mechanisms to Produce Size-Controlled, Tailored Nanocrystals for Optoelectronic and Catalytic Applications: A Review.ACS applied nano materials · 2024Review
- An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biphasic NMR of Hyperpolarized Suspensions-Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Article
- Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- A Biomimetic, Silaffin R5-Based Antigen Delivery Platform.Pharmaceutics · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The most advanced materials are those found in nature. These evolutionary optimized substances provide highest efficiencies, e.g., in harvesting solar energy or providing extreme stability, and are intrinsically biocompatible. However, the mimicry of biological materials is limited to a few successful applications since there is still a lack of the tools to recreate natural materials. Herein, such means are provided based on a peptide library derived from the silaffin protein R5 that enables rational biomimetic materials design. It is now evident that biomaterials do not form via mechanisms observed in vitro. Instead, the material's function and morphology are predetermined by precursors that self-assemble in solution, often from a combination of protein and salts. These assemblies act as templates for biomaterials. The RRIL peptides used here are a small part of the silica-precipitation machinery in diatoms. By connecting RRIL motifs via varying central bi- or trifunctional residues, a library of stereoisomers is generated, which allows characterization of different template structures in the presence of phosphate ions by combining residue-resolved real-time NMR spectroscopy and molecular dynamics (MD) simulations. Understanding these templates in atomistic detail, the morphology of silica particles is controlled via manipulation of the template precursors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.