Evidence map›Paper›PMID 36509935›Full record

SynthesisJournal of gastrointestinal cancer2023

Exercise and Nutritional Interventions in Patients with Advanced Gastroesophageal Cancer: A Systematic Review.

Joost Besseling, Merel van Velzen, Nicolette Wierdsma, Kelly Silverio Alonso-Duin, Peter Weijs, Anne M May, Hanneke van Laarhoven

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Health-related quality of life in esophageal cancer: a state-of-the-art review of patient-reported outcomes and an evidence and gap map.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joost BesselingDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, De Boelelaan 1117, room ZH-3A46, 1081 HV, Amsterdam, Netherlands.
Merel van VelzenDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, De Boelelaan 1117, room ZH-3A46, 1081 HV, Amsterdam, Netherlands.
Nicolette WierdsmaDepartment of Nutrition & Dietetics, Amsterdam UMC, Amsterdam, Netherlands.
Kelly Silverio Alonso-DuinDepartment of Nutrition & Dietetics, Amsterdam UMC, Amsterdam, Netherlands.
Peter WeijsDepartment of Nutrition & Dietetics, Amsterdam UMC, Amsterdam, Netherlands.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.
Hanneke van LaarhovenDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, De Boelelaan 1117, room ZH-3A46, 1081 HV, Amsterdam, Netherlands. h.vanlaarhoven@amsterdamumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe quality of life and survival of patients with advanced gastroesophageal cancer can be improved. Positive effects of exercise and nutritional interventions on quality of life and potential effects on cancer outcomes are found in gastroesophageal cancer in the curative setting, as well as in other cancer types. We therefore systematically reviewed the current literature on the effect of exercise and nutritional interventions on various outcomes in patients with advanced gastroesophageal cancer.

methodsWe searched on the 11th of June 2021 in Pubmed, Embase and the Cochrane library for publications of randomized trials and observational studies on exercise and nutritional interventions (either combined or as separate intervention) in patients with advanced gastroesophageal cancer. The outcomes of interest were overall survival, progression free survival, quality of life, chemotherapy toxicity, and chemotherapy adherence.

resultsWe screened 1,764 records for eligibility and included one study in our analysis. The other 1,763 were excluded for various reasons, most frequently an incorrect study population (e.g. both curable and incurable patients) or an incorrect intervention. One retrospective cohort study of 40 patients with advanced gastric cancer who received first line chemotherapy was included. It was stated that 'no significant differences in terms of overall and progression free survival were reported between the two groups of patients.' No absolute numbers were provided.

conclusionOur systematic review did not identify any high quality studies on exercise and nutritional interventions in advanced gastroesophageal cancer. We deem a randomized clinical trial on this topic to be highly needed.

Indexed as

Esophageal NeoplasmsStomach NeoplasmsExerciseHumansQuality of LifeRandomized Controlled Trials as TopicRetrospective StudiesEsophageal cancerExerciseGastric cancerNutrition therapySystematic review

Identifiers

PMID36509935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.