ArticleJournal of perinatology : official journal of the California Perinatal Association2023
Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Inhaled nitric oxide in preterm infants with respiratory disease: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies.Pediatric research · 2026Review
- Does inhaled nitric oxide treatment of pulmonary hypertension in extremely premature infants improve patient outcomes?Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Outcomes of Infants Born at 21 Weeks' Gestational Age.JAMA network open · 2025Article
- Sound Waves Versus Pressure Waves: The Increasing Role of Echocardiography and Noninvasive Vasoreactivity Testing in Pediatric Pulmonary Hypertension Management.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Association between nitric oxide treatment and intraventricular hemorrhage among extremely preterm neonates in Switzerland, 2012-2020.Scientific reports · 2025Article
- Clinical Analysis of Inhaled Nitric Oxide Therapy in Preterm Infants at Different Gestational Ages: A National Retrospective Multicenter Study.American journal of perinatology · 2025Article
- It's the little things. A framework and guidance for programs to care for infants 22-23 weeks' gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Response to Inhaled Nitric Oxide and Mortality Among Very Preterm Neonates With Pulmonary Hypertension.JAMA network open · 2025Observational
- Scoping review of initiation criteria for inhaled nitric oxide in preterm infants (born <34 weeks) after 7 days of age.BMJ open · 2024Article
- A multicenter epidemiological survey of iNO use in preterm infants in China.Pediatric pulmonology · 2024Article
- Inhaled nitric oxide therapy for preterm infants after 7 days of age: a scoping review protocol.BMJ open · 2024Article
- [Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the outcomes of extremely premature infants who received inhaled nitric oxide(iNO) for hypoxic respiratory failure(HRF). STUDY
designRetrospective analysis of 107 infants born 22-26 weeks gestation who received iNO for HRF at a single institution. Infants were categorized as positive, negative, or no responders based on change in FiO
results63% of infants had a positive response; they received iNO earlier and were more likely to have acute pulmonary hypertension(PH). Positive response correlated with decreased incidence of death or grade 3 BPD at 36 weeks postmenstrual age, as compared to a negative response.
conclusionsExtremely premature infants have a positive response rate to iNO comparable to term infants when used for PH in the transitional period. Infants with a negative response to iNO had worse outcomes, necessitating the determination of the underlying physiology of HRF prior to iNO initiation.
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Registered trials
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