ArticleNature communications2022
Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Toxicological Assessment of the Marine-Derived Cyclic Dipeptide Cyclo(Pro-Tyr) Using In Vitro, Zebrafish Embryo, and BALB/c Mouse Models.Journal of xenobiotics · 2026Article
- Sex-Specific Pathophysiological Signatures in Allometric Dosing-Controlled Bleomycin Acute Lung Injury Model.bioRxiv : the preprint server for biology · 2026Article
- Wild-Derived House Mice (Mus musculus) Are Able to Cope With a Constant Light Environment.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- New approaches to meta-analyze differences in skewness, kurtosis, and correlation.PLoS biology · 2026Article
- A visualization tool for individual gene expression profiles among males and females in GTEx tissues.Biology of sex differences · 2025Article
- Integrating gender medicine into modern healthcare: Progress and barriers.European journal of clinical investigation · 2025Review
- IMPC impact on preclinical mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Hepatotoxicity associated with anti-neoplastic agents: a pharmacovigilance analysis of the Food and Drug Administration Adverse Event Reporting System database.Frontiers in immunology · 2025Article
- Detachable DNA Assembly Module to Dissect Tumor Cells Heterogeneity via RNA Pinpoint Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Zoographics in the Journal of the Experimental Analysis of Behavior: Increasing inclusion of female animals.Journal of the experimental analysis of behavior · 2024Article
- Genetic hypogonadal (Gnrh1bioRxiv : the preprint server for biology · 2024Article
- Article
- Article
- Temperature and nutrition do not interact to shape the evolution of metabolic rate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases.F1000Research · 2024Article
- Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy.PLoS neglected tropical diseases · 2024Article
- Why and How to Account for Sex and Gender in Brain and Behavioral Research.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Unmasking the Adverse Impacts of Sex Bias on Science and Research Animal Welfare.Animals : an open access journal from MDPI · 2023Review
- Interactions between Gender and Sepsis-Implications for the Future.Microorganisms · 2023Review
- Sexual dimorphism in skull size and shape ofPeerJ · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Sex differences in the lifetime risk and expression of disease are well-known. Preclinical research targeted at improving treatment, increasing health span, and reducing the financial burden of health care, has mostly been conducted on male animals and cells. The extent to which sex differences in phenotypic traits are explained by sex differences in body weight remains unclear. We quantify sex differences in the allometric relationship between trait value and body weight for 363 phenotypic traits in male and female mice, recorded in >2 million measurements from the International Mouse Phenotyping Consortium. We find sex differences in allometric parameters (slope, intercept, residual SD) are common (73% traits). Body weight differences do not explain all sex differences in trait values but scaling by weight may be useful for some traits. Our results show sex differences in phenotypic traits are trait-specific, promoting case-specific approaches to drug dosage scaled by body weight in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.