Evidence map›Paper›PMID 36509249›Full record

ArticleContemporary clinical trials2023

Protocol for a study on Sitting with Interruption and Whole-Body Cardiovascular Health (SWITCH) in middle-aged adults.

Simon Higgins, Emma S Cowley, Craig Paterson, Erik D Hanson, Gaurav J Dave, Michelle L Meyer, Feng-Chang Lin, Bethany Barone Gibbs, Maihan Vu, Lee Stoner

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05316571 (Sitting Interruption and Whole-body Cardiovascular Health), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05316571 narecruitingnot on this map

Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk Behaviors

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2026Enrolled56ConditionsSedentary Behavior, Sedentary TimeArmsOne 5-Minute Walking Bout Each Hour, One 15-Minute Standing Bout Each Hour, One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour, Uninterrupted Sitting
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Simon HigginsDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: higginss@unc.edu.
Emma S CowleyDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Craig PatersonDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Erik D HansonDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gaurav J DaveDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michelle L MeyerDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Depart of Epidemiology, Gillings School of Global Public Health; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Feng-Chang LinDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Bethany Barone GibbsDepartment of Epidemiology and Biostatistics, West Virginia University, Morgantown, WV, USA.
Maihan VuCenter for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lee StonerDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Depart of Epidemiology, Gillings School of Global Public Health; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USWest Virginia University · US

Funding

Sitting Interruption and Whole-body Cardiovascular Health: Linking Physiological Responses to Risk BehaviorsR01HL157187 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HANSON, ERIK D · 2022 to 2025
$2.5M
Cardiometabolic Disease Prevention in College-based Young Adults: Mapping a Contextual Sedentary Behavior InterventionR01HL162805 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HANSON, ERIK D · 2022 to 2025
$2.2M
NHLBI NIH HHS R01 HL157187NHLBI NIH HHS R01 HL162805
6 · The paper itself

Abstract

backgroundSedentary behavior (SB) is a biologically distinct yet understudied cardiovascular disease risk (CVD) factor. However, specific public health policy regarding the optimal strategy for SB interruption is unavailable. This paper outlines the protocol for part I of the Sitting with Interruption and Whole-Body Cardiovascular Health (SWITCH) study, including the rationale, objectives, methodology, and next steps. We additionally detail practical considerations that went into the development of the NIH R01 grant supporting this research.

methodsHealthy men and women (n = 56, aged 36-55) who are inactive (<90 min/wk. of moderate-to-vigorous intensity physical activities for past 3 months) and sedentary (sitting for >8 h/day), will be recruited for this randomized crossover trial. Specifically, participants will complete the following 4-h conditions: (i) SB with once/h 5 min walk break; (ii) SB with once/h 15 min stand break; (iii) SB with twice/h breaks (alternating 5 min walk and 15 min stand); and (iv) SB with no breaks (i.e., control). Focus group discussions will refine our socioecological SB reduction model.

resultsThe primary outcome will be change in aortic arterial stiffness (i.e., pulse wave velocity; PWV, m/s) for each substitution strategy relative to the control (SB with no breaks) condition.

conclusionsThe outcomes from this study will facilitate the design of a subsequent randomized controlled trial to test a mechanism-informed, feasible SB-reduction intervention and support the development of SB policy.

Indexed as

ExerciseVascular StiffnessAdultFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedPulse Wave AnalysisRandomized Controlled Trials as TopicSedentary BehaviorArterial stiffnessCardiovascularPathophysiologyPublic policySedentary behavior

Identifiers

PMID36509249
PMCPMC9918673
OpenAlexW4311457506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.