Evidence map›Paper›PMID 36509178›Full record

ArticleThe Canadian journal of cardiology2023

Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19.

Rashmin Hira, Jacquie R Baker, Tanya Siddiqui, Shaun I Ranada, Ateyeh Soroush, Kavithra Karalasingham, Hyeqa Ahmad, Vibhuti Mavai, Luciano Martin Ayala Valani, Sakina Ambreen and 6 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in The Canadian journal of cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Beyond the headache: autonomic reflex dysfunction and heightened sensory sensitivity contribute to orthostatic intolerance in migraine.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Article
  4. Letter to the editor regarding "Chronic autonomic symptom burden in long-COVID: a follow-up cohort study."Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  5. Response to letter by Zadeh et al. regarding "Chronic autonomic symptom burden in long-COVID: a follow-up cohort study".Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  6. Article
  7. Article
  8. Minimal Objective Autonomic Dysfunction in Long COVID.Journal of the American College of Cardiology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Chronic autonomic symptom burden in long-COVID: a follow-up cohort study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
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  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Rashmin HiraDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jacquie R BakerDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Tanya SiddiquiDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Shaun I RanadaDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ateyeh SoroushDepartment of Neuroscience, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Kavithra KaralasinghamDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Hyeqa AhmadDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Vibhuti MavaiDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Luciano Martin Ayala ValaniDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sakina AmbreenDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Kate M BourneDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Matthew G LloydDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Carlos A MorilloDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Robert S SheldonDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Satish R RajDepartment of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address: satish.raj@ucalgary.ca.
Canadian Long COVID Autonomic Network (CanLoCAN)
University of Calgary · CA

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

backgroundMany COVID-19 patients are left with symptoms several months after resolution of the acute illness; this syndrome is known as post-acute sequalae of COVID-19 (PASC). We aimed to determine the prevalence of objective hemodynamic cardiovascular autonomic abnormalities (CAA), explore sex differences, and assess the prevalence of CAA among hospitalized vs nonhospitalized patients with PASC.

methodsPatients with PASC (n = 70; female [F] = 56; 42 years of age; 95% confidence interval [CI], 40-48) completed standard autonomic tests, including an active stand test 399 days (338, 455) after their COVID-19 infection. Clinical autonomic abnormalities were evaluated.

resultsMost patients with PASC met the criteria for at least 1 CAA (51; 73%; F = 43). The postural orthostatic tachycardia syndrome hemodynamic (POTS

conclusionsPatients with PASC have evidence of CAA, most commonly IOH

Indexed as

Cardiovascular SystemCOVID-19Hypotension, OrthostaticAutonomic Nervous SystemDisease ProgressionFemaleHemodynamicsHumansMale

Identifiers

PMID36509178
PMCPMC9733966
OpenAlexW4311148176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.