Evidence map›Paper›PMID 36508986›Full record

ArticleRespiratory medicine2023

Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood.

Francesca Polverino, Debra A Stern, Eric M Snyder, Courtney Wheatley-Guy, Surya P Bhatt, Fernando D Martinez, Stefano Guerra, Wayne J Morgan

Open access · hybridAbstract read
In one paragraph

Article in Respiratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. The Developmental Origins of Asthma and COPD.Annual review of physiology · 2026
    Review
  2. Article
  3. Review
  4. Dysanapsis as a Determinant of Lung Function in Development and Disease.American journal of respiratory and critical care medicine · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Francesca PolverinoAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 85719, USA; Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, 77030, USA. Electronic address: fpolverino@copdnet.org.
Debra A SternAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 85719, USA.
Eric M SnyderGeneticure, Rochester, MN, 55902, USA.
Courtney Wheatley-GuyCardiovascular Diseases, Mayo Clinic Scottsdale, Scottsdale, AZ, 85259, USA.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35924, USA.
Fernando D MartinezAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 85719, USA.
Stefano GuerraAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 85719, USA.
Wayne J MorganAsthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, 85719, USA.
University of Arizona · USMayo Clinic in Arizona · USUniversity of Alabama at Birmingham · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Early Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of LifeR01HL132523 · NHLBI · UNIVERSITY OF ARIZONA · PI Stefano Guerra, Fernando D Martinez · 2016 to 2026
$15.1M
Tollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA · 2016 to 2025
$14.7M
CC16 in Childhood and Resilience to Persistent Asthma into Adult Life (Supplement)R01AI135108 · NIAID · UNIVERSITY OF ARIZONA · PI Stefano Guerra · 2017 to 2026
$5.4M
B cell-adaptive Immune Profile in Emphysema-predominant COPDR01HL149744 · NHLBI · UNIVERSITY OF ARIZONA · PI POLVERINO, FRANCESCA · 2020 to 2024
$3.4M
NHLBI NIH HHS R01 HL132523NHLBI NIH HHS R01 HL149744NIAID NIH HHS R01 AI135108NIAID NIH HHS U19 AI125357NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.

Indexed as

LungAdultChildChild, PreschoolHumansRisk FactorsYoung Adult

Identifiers

PMID36508986
PMCPMC10389168
OpenAlexW4310062070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.