ArticleThe clinical respiratory journal2023
The value of concentration of alveolar nitric oxide in diagnosing small airway dysfunction in patients with stable asthma.
Article in The clinical respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Fractional exhaled nitric oxide at multiple flow rates in chronic cough: association with lung function and airway hyperresponsiveness.Annals of medicine · 2026Article
- Distal Airway Inflammation Is Linked to Small Airway Dysfunction in Asthma.Medical sciences (Basel, Switzerland) · 2026Observational
- Clinical Utility of Central and Peripheral Airway Nitric Oxide in Children with Different Types of Allergic Asthma.Journal of asthma and allergy · 2025Article
- Analysis of the correlations and inconsistencies between spirometry and impulse oscillometry in the diagnosis of small-airway dysfunction.BMC pulmonary medicine · 2024Article
- Identification and treatment of persistent small airway dysfunction in paediatric patients with asthma: a retrospective cohort study.BMC pulmonary medicine · 2024Article
- Differential Clinical Significance of FENOJournal of asthma and allergy · 2024Article
- The value of concentration of alveolar nitric oxide in diagnosing small airway dysfunction in patients with stable asthma.The clinical respiratory journal · 2023Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundExhaled nitric oxide (FeNO) is a simple, noninvasive, and reproducible test, and FeNO (50 ml/s) is often used to reflect airway inflammation. The peripheral small airway/alveolar nitric oxide (NO) concentration is derived from the output of NO at multiple flow rates. Concentration of alveolar NO (CANO), which has been reported to reflect peripheral small airway inflammation, may be related to parameters that reflect abnormal small airway function.
aimThis study aims to investigate the relationship among CANO levels, clinical features, and small airway function-related indicators in patients with stable asthma and to provide a simple method for monitoring small airway function in asthma. DESIGN AND
methodsWe recruited 144 patients with well-controlled, stable asthma, including 69 patients with normal small airway function (normal group) and 75 patients with small airway dysfunction (abnormal group). CANO and pulmonary function were measured.
resultsCANO was significantly higher in the abnormal group ([7.28 ± 3.25] ppb) than the normal group CANO ([2.87 ± 1.50] ppb). FEF25-75%pred ([55.0 ± 16.5]%), FEF50%pred ([46.4 ± 13.2]%), and FEF75%pred ([41.9 ± 13.1]%) in abnormal group were significantly lower compared with normal group ([89.9 ± 7.5]%), ([80.9 ± 6.8]%), and ([73.8 ± 5.0]%). CANO was negatively correlated and FEF25-75%pred, FEF50%pred, and FEF75%pred (r = -0.87, P < 0.001; r = -0.82, P < 0.001; r = -0.78, P < 0.001). CANO was positively correlated with age (r = 0.27, P = 0.001). The area under the ROC curve was 0.875 for CANO. The optimal cutoff point of 5.3 ppb had sensitivity and specificity values of 72% and 92% in diagnosing small airway dysfunction.
conclusionCANO has diagnostic value for small airway dysfunction, and the optimal cutoff value is 5.3 ppb. However, the diagnostic evidence is still insufficient, so it still needs further exploration for its value in detecting small airway dysfunction.
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