Evidence map›Paper›PMID 36508698›Full record

ArticleJCO oncology practice2023

Substance Use Among Young Adult Survivors of Childhood Cancer With Cognitive Impairment: An Analysis of the Project Forward Cohort.

Ding Quan Ng, Anamara Ritt-Olson, David R Freyer, Kimberly A Miller, Stefanie M Thomas, Joel Milam, Alexandre Chan

Open access · hybridAbstract read
In one paragraph

Article in JCO oncology practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Cannabis use among cancer survivors: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2026
    Pooled it
  2. Review
  3. Sociodemographic disparities and reasons for delayed healthcare among U.S. cancer survivors: an All of Us study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cannabis Use Among Adolescents and Young Adults with Cancer: A Scoping Review.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ding Quan NgDepartment of Clinical Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, Irvine, CA.ORCID 0000-0002-0754-7901
Anamara Ritt-OlsonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
David R FreyerDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.ORCID 0000-0001-5280-990X
Kimberly A MillerDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.ORCID 0000-0002-0742-3730
Stefanie M ThomasPediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic, Cleveland, OH.
Joel MilamDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Alexandre ChanDepartment of Clinical Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, Irvine, CA.ORCID 0000-0003-4391-4219
University of Southern California · USUniversity of California, Irvine · USCleveland Clinic · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Reducing racial/ethnic inequities in childhood cancer survivorshipR01MD007801 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 2014 to 2018
$2.1M
NCI NIH HHS P30 CA014089NIMHD NIH HHS R01 MD007801
6 · The paper itself

Abstract

purposeYoung adult childhood cancer survivors (YACCSs) are often impacted by cancer-related cognitive impairment (CRCI) and psychological distress. Using the Project Forward Cohort, we evaluated the relationship between CRCI and substance use behaviors.

methodsYACCSs were surveyed between 2015 and 2018 (N = 1,106, female = 50.8%, Hispanic = 51.5%, median age = 25.5 years). Associations between CRCI and substance use (tobacco, binge drinking, marijuana, prescription drug misuse, and e-cigarette/vaporizer) were examined in multivariate logistic or log-binomial regressions, adjusting for child at diagnosis (0-14 years), years since diagnosis, sex, race/ethnicity, cancer type, and treatment intensity. Mediation analysis was performed to determine opportunities for interventions.

resultsCRCI was reported by 144 (13.0%) survivors. The highest prevalence was observed in CNS cancers (25.4%) and leukemia (13.3%) survivors. After covariate adjustment, CRCI was associated with 2.26 times the odds of prior 30-day vaping (95% CI, 1.24 to 4.11;

conclusionCRCI among YACCSs was associated with reports of vaping. Oncologists should screen for vaping behavior if CRCI is apparent. Increasing access to long-term follow-up clinics, addressing physical and mental health issues, and monitoring and educating on vaping and other substance use behaviors is recommended to improve the long-term health of YACCSs.

Indexed as

Cancer SurvivorsCognitive DysfunctionElectronic Nicotine Delivery SystemsNeoplasmsSubstance-Related DisordersAdultChildFemaleHumansSurvivorsYoung Adult

Identifiers

PMID36508698
PMCPMC10022886
OpenAlexW4311187430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.