ArticleProceedings of the National Academy of Sciences of the United States of America2022
The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Shedding light on pain management: a translational systematic review of light therapy for the treatment of chronic pain.EBioMedicine · 2026Pooled it
- Impact of repeated morning bright white light exposures on attention in a simulated office environment.Scientific reports · 2023Trial
- Considerations and guidelines for photic measurement in field studies of the physiological effects of light.Npj biological timing and sleep · 2026Review
- Evaluation of wearable light dosimeters for circadian lighting: spectral, spatial, photometric, melanopic, and thermal performance.Npj biological timing and sleep · 2026Article
- Review
- Nocturnal Dim Blue Light Is Associated with Splenic Immune Dysregulation and Altered CORT-GR Signalling in High-Fat-Diet-Fed Mice.Antioxidants (Basel, Switzerland) · 2026Article
- Home lighting, blue-light filtering, and their effects on melatonin suppression.Scientific reports · 2026Article
- Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review).Molecular medicine reports · 2026Review
- IMI-Interventions for Controlling Myopia Onset and Progression 2025.Investigative ophthalmology & visual science · 2025Review
- Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.iScience · 2025Article
- Stimulus conditions eliciting sneezing in response to bright light.Experimental brain research · 2025Review
- Reconsidering the spectral distribution of light: Do people perceive watts or photons?Lighting research & technology (London, England : 2001) · 2024Article
- Towards an evidence-based integrative lighting score: a proposed multi-level approach.Annals of medicine · 2024Review
- Behavioural determinants of physiologically-relevant light exposure.Communications psychology · 2024Review
- Lighting the path forward: the value of sleep- and circadian-informed lighting interventions in shift work.Sleep · 2024Article
- Wearable Light Loggers in Field Conditions: Corneal Light Characteristics, User Compliance, and Acceptance.Clocks & sleep · 2024Article
- Toward an Indoor Lighting Solution for Social Jet Lag.Journal of biological rhythms · 2024Article
- Mathematical Analysis of Light-sensitivity Related Challenges in Assessment of the Intrinsic Period of the Human Circadian Pacemaker.Journal of biological rhythms · 2024Article
- Effects of calibrated blue-yellow changes in light on the human circadian clock.Nature human behaviour · 2024Article
- A perspective on the Festschrift of Charles A. Czeisler, PhD MD.Sleep health · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
Abstract
Human circadian, neuroendocrine, and neurobehavioral responses to light are mediated primarily by melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) but they also receive input from visual photoreceptors. Relative photoreceptor contributions are irradiance- and duration-dependent but results for long-duration light exposures are limited. We constructed irradiance-response curves and action spectra for melatonin suppression and circadian resetting responses in participants exposed to 6.5-h monochromatic 420, 460, 480, 507, 555, or 620 nm light exposures initiated near the onset of nocturnal melatonin secretion. Melatonin suppression and phase resetting action spectra were best fit by a single-opsin template with lambda
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.