Evidence map›Paper›PMID 36508051›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Language barriers and kidney transplantation in children.

Stephanie P Kerkvliet, Carlos J Perez Kerkvliet, Ziou Jiang, Michael Evans, Sarah J Kizilbash

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stephanie P KerkvlietDepartment of Pediatrics, University of Minnesota, Minneapolis, USA. kerkvliets@chop.edu.ORCID http://orcid.org/0000-0002-0036-5427
Carlos J Perez KerkvlietUniversity of Minnesota Medical School, Minneapolis, USA.ORCID http://orcid.org/0000-0003-2530-840X
Ziou JiangUniversity of Minnesota Clinical and Translational Science Institute, Minneapolis, USA.ORCID http://orcid.org/0000-0002-4063-5671
Michael EvansUniversity of Minnesota Clinical and Translational Science Institute, Minneapolis, USA.ORCID http://orcid.org/0000-0001-7449-3993
Sarah J KizilbashDepartment of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, USA.ORCID http://orcid.org/0000-0001-5824-7856
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
PhosphoSer134 GR, TGF-β and 14-3-3-zeta cooperate to promote progression of Triple Negative Breast CancerF30CA228261 · NCI · UNIVERSITY OF MINNESOTA · PI PEREZ KERKVLIET, CARLOS JESUS · 2019 to 2021
$152k
NCATS NIH HHS UL1TR002494NCI NIH HHS F30 CA228261NCI NIH HHS T32 CA009138NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

backgroundUnderstanding disparities in pediatric kidney transplants is important to provide equitable care. We compared transplant outcomes between English-speaking (ES) and interpreter-needing (IN) pediatric kidney transplant recipients.

methodsThrough retrospective review, primary kidney transplant recipients, 0-21 years transplanted between 2005 and 2019, were divided into ES and IN cohorts. Continuous and categorical variables were compared using Wilcoxon rank-sum, Welch two-sample t-test, and chi-squared analyses. Patient survival, graft survival, and rejection-free survival were evaluated using Kaplan-Meier methods and Cox regression. Days hospitalized were evaluated using negative binomial regression.

resultsOur sample included 211 ES and 37 IN transplant recipients. Compared with the ES, the IN cohort was older at transplant (14.56 vs. 11.03 years; p < 0.01), had more time between kidney failure and transplant (0.9 vs. 0.3 years; p < 0.01), and more often received deceased over living donor transplants (78.4% vs. 30.4%; p < 0.01). Multivariate Cox proportional-hazard models evaluating adjusted 5-year patient survival demonstrated decreased 5-year post-transplant survival in the IN cohort (aHR = 10.10, 95% CI: 1.5, 66.8; p = 0.02). We did not identify differences in 5-year death-censored graft survival (aHR = 0.57; 95% CI: 0.14, 2.4; p = 0.4) nor rejection-free survival (aHR = 0.8; 95% CI: 0.4, 1.5; p = 0.5). We found significantly fewer hospitalization events in the IN cohort during the first year post-transplant (aRR: 0.62; 95% CI: 0.4, 0.9; p = 0.01) but no difference 5-year post-transplant. The IN cohort had more missed outpatient appointments (10.4% vs. 2.8%; p = 0.03) and undetectable serum immunosuppressant levels (mean: 3.8% vs. 1.3%; p = 0.02) 5 years post-transplant.

conclusionsPediatric kidney transplant recipients requiring interpreter services for healthcare delivery demonstrate fewer post-transplant interactions with their healthcare team (fewer hospitalizations and more no-show visits) and lower 5-year patient survival compared with recipients not requiring interpreters. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Kidney TransplantationChildCommunication BarriersGraft RejectionGraft SurvivalHumansLiving DonorsProportional Hazards ModelsRetrospective StudiesTreatment OutcomeInterpreterKidney transplantLanguage barrierLimited English proficiencyPediatric

Identifiers

PMID36508051
OpenAlexW4311203640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.