Evidence map›Paper›PMID 36507965›Full record

ArticleMolecular biology reports2023

Angiotensin-converting enzyme gene (ACE) polymorphisms are associated with dysregulation of biochemical parameters in hypertensive patients.

Lívia da Agostini, Warlley R Cunha, Nayara N T Silva, André S Melo, Luciana B Moreira, Tamires C Almeida, Vanessa A Belo, Wendel Coura-Vital, Luiz Fernando de M Teixeira, Angélica A Lima and 1 more

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lívia da AgostiniFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Warlley R CunhaFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Nayara N T SilvaFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
André S MeloFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Luciana B MoreiraFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Tamires C AlmeidaFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Vanessa A BeloFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Wendel Coura-VitalFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Luiz Fernando de M TeixeiraFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Angélica A LimaFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil.
Glenda Nicioli da SilvaFederal University of Ouro, Morro do Cruzeiro, s/nº, CEP 35400-000, Preto, Ouro Preto, Minas Gerais, Brazil. nicioli@ufop.edu.br.
Universidade Federal de Ouro Preto · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 310905/2020-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Ouro Preto Municipal Health Department 18.295.295/0001-36Pró-Reitoria de Pesquisa e Pós-Graduação, Universidade Federal de Ouro Preto 23109.004080/2019-88
6 · The paper itself

Abstract

introductionThe genetic component, including genes and their variants, plays a significant role in the pathophysiology of arterial hypertension (AH). Thus, clinical, epidemiological and genetic studies have been carried out to improve the understanding of disease mechanisms, improve diagnostic quality and contribute to prevention.

objectiveTo determine the association of risk factors, biochemical parameters and different ACE gene polymorphisms with AH.

methodThe case-control study was carried out in the population of Ouro Preto, Brazil. The subjects answered a questionnaire containing clinical and sociodemographic data. The ACE gene polymorphisms rs4291, rs4363 and rs4335 were evaluated by real time-polymerase chain reaction (real-time PCR) in 310 people (155 hypertensive and 155 normotensive patients), in addition to biochemical parameters. A multivariate logistic regression model was used to identify factors associated with AH. Analysis of continuous variables was performed using the Kruskal-Wallis test to assess significance between groups and Dunn's post-test for multiple comparisons.

resultsThe results showed that AH was associated with age, education, smoking, obesity and high levels of triglycerides, sodium, glucose and uric acid. Regarding the biochemical parameters, in hypertensive patients, the rs4363 and rs4335 polymorphisms were associated with high levels of triglycerides, urea and glucose; the rs4291 polymorphism was associated with elevated urea and glucose levels. No association was detected between SNPs and HA.

conclusionAH was associated with socioeconomic status, lifestyle habits and biochemical parameters. ACE polymorphisms may have influenced the levels of triglycerides, urea and glucose in hypertensive patients.

Indexed as

HypertensionPeptidyl-Dipeptidase AAngiotensinsCase-Control StudiesGenotypeHumansPolymorphism, Single NucleotideTriglyceridesACE protein, humanAngiotensinsPeptidyl-Dipeptidase ATriglyceridesAngiotensin converting enzymeArterial hypertensionGenetic polymorphismRisk factors

Identifiers

PMID36507965
OpenAlexW4311131079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.