Evidence map›Paper›PMID 36507833›Full record

ArticlemBio2023

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics.

Aaron C Nolan, Merve S Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M Corrigan, Angelika Gründling, James P O'Gara

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
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  9. Mutation of lipoprotein processing pathway geneAntimicrobial agents and chemotherapy · 2026
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  10. BeyondAntimicrobial agents and chemotherapy · 2026
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  11. Article
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  13. Regulation of potassium homeostasis inFrontiers in microbiology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Aaron C Nolan *Microbiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Merve S Zeden *Microbiology, School of Biological and Chemical Sciences, University of Galway, Ireland.ORCID 0000-0003-3636-700X
Igor KviatkovskiSection of Molecular Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Christopher CampbellMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Lucy UrwinThe Florey Institute, School of Bioscience, University of Sheffield, Sheffield, United Kingdom.
Rebecca M CorriganThe Florey Institute, School of Bioscience, University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0002-6031-1148
Angelika GründlingSection of Molecular Microbiology and Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.ORCID 0000-0002-6235-8687
James P O'GaraMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.ORCID 0000-0003-3866-7161
Ollscoil na Gaillimhe – University of Galway · IEImperial College London · GBUniversity of Sheffield · GB

Funding

Wellcome TrustWellcome Trust 104110/Z/14/AWellcome Trust 210671/Z/18/Z/WT
6 · The paper itself

Abstract

The purine-derived signaling molecules c-di-AMP and (p)ppGpp control

Indexed as

Methicillin-Resistant Staphylococcus aureusAdenosine TriphosphateAnti-Bacterial AgentsBacterial Proteinsbeta-Lactam Resistancebeta-LactamsDinucleoside PhosphatesGuanosineGuanosine TriphosphateMicrobial Sensitivity TestsMonobactamsOxacillinPenicillin-Binding ProteinsPurine NucleosidesAdenosine TriphosphateAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamscyclic diadenosine phosphateDinucleoside PhosphatesGuanosineGuanosine TriphosphateMonobactamsOxacillinPenicillin-Binding ProteinsPurine Nucleosidesantibiotic adjuvantantibiotic resistancec-di-AMPMRSApurine metabolismStaphylococcus aureusβ-lactam resistance

Identifiers

PMID36507833
PMCPMC9973305
OpenAlexW4311204579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.