Mapping white matter structural covariance connectivity for single subject using wavelet transform with T1-weighted anatomical brain MRI.

Introduction: Current studies of structural covariance networks were focused on the gray matter in the human brain. The structural covariance connectivity in the white matter remains largely unexplored. This paper aimed to build novel metrics that can infer white matter structural covariance connectivity, and to explore the predictive power of the proposed features. Methods: To this end, a cohort of 315 adult subjects with the anatomical brain MRI datasets were obtained from the publicly available Dallas Lifespan Brain Study (DLBS) project. The 3D wavelet transform was applied on the individual voxel-based morphology (VBM) volume to obtain the white matter structural covariance connectivity. The predictive models for cognitive functions were built using support vector regression (SVR). Results: The predictive models exhibited comparable performance with previous studies. The novel features successfully predicted the individual ability of digit comparison (DC) ( Discussion: The results suggested that the white matter structural covariance connectivity was informative and had potential for predictive tasks of brain-behavior research.