ArticleFrontiers in bioengineering and biotechnology2022
Fabrication of a controlled-release delivery system for relieving sciatica nerve pain using an ultrasound-responsive microcapsule.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Revolutionizing neural regeneration with smart responsive materials: Current insights and future prospects.Bioactive materials · 2025Review
- Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release.Pharmaceutics · 2025Article
- Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system.Advanced drug delivery reviews · 2024Review
- Targeted local anesthesia: a novel slow-release FeJournal of anesthesia · 2024Article
- Novel Drug Targets and Emerging Pharmacotherapies in Neuropathic Pain.Pharmaceutics · 2023Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lidocaine, a potent local anesthetic, is clinically used in nerve block and pain management. However, due to its short half-life, repeated administration is required. For this reason, here we designed and prepared a lidocaine-encapsulated polylactic acid-glycolic acid (Lidocaine@PLGA) microcapsule with ultrasound responsiveness to relieve the sciatica nerve pain. With a premixed membrane emulsification strategy, the fabricated lidocaine-embedded microcapsules possessed uniform particle size, good stability, injectability, and long-term sustained release both
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