ReviewOxidative medicine and cellular longevity2022
Iron Metabolism and Ferroptosis in Peripheral Nerve Injury.
Review in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Close relationship between β2-microglobulin and type 2 diabetes-associated peripheral neuropathy.Journal of diabetes investigation · 2026Article
- Quantitative susceptibility mapping reveals abnormal iron reduction in deep gray matter of children with global developmental delay.Pediatric radiology · 2026Article
- Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review.Journal of cellular and molecular medicine · 2026Review
- CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.Inflammation · 2026Article
- A dual-action nanoparticle approach for spinal cord injury treatment: ferroptosis inhibition, inflammation control, and Myelin preservation.Journal of nanobiotechnology · 2026Article
- Research progress on the regulation of ferroptosis in NPC (Review).Oncology reports · 2026Review
- Pituitary adenylate cyclase-activating polypeptide and mitochondrial homeostasis in neuronal injury: mechanisms and translational prospects.Frontiers in immunology · 2026Review
- Spinal motor neuron degeneration after brachial plexus avulsion: mechanisms and therapeutic targets.Frontiers in neuroscience · 2026Review
- The interaction between oxidative stress and Schwann cells.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Unlocking the benefits of aerobic exercise for MAFLD: a comprehensive mechanistic analysis.Journal of translational medicine · 2025Review
- Ferroptosis in cancer: metabolism, mechanisms and therapeutic prospects.Molecular cancer · 2025Review
- Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction.The Kaohsiung journal of medical sciences · 2025Article
- Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway.Journal of orthopaedic surgery and research · 2025Article
- Electroacupuncture Inhibits Ferroptosis by Modulating Iron Metabolism and Oxidative Stress to Alleviate Cerebral Ischemia-Reperfusion Injury.Journal of molecular neuroscience : MN · 2025Article
- Production and Role of Free Radicals and Reactive Oxygen Species After Facial Nerve Injury.Antioxidants (Basel, Switzerland) · 2025Review
- Modulating Ferroptosis: A Novel Approach to Promote Neural Repair in Brain Injury.Current neuropharmacology · 2025Review
- Advances in adhesion interfaces of peripheral nerve repair materials: mechanism, classification, evaluation method, and functionalization.Frontiers in cell and developmental biology · 2025Review
- Ferroptosis in NAFLD: insights and the therapeutic potential of exercise.Frontiers in medicine · 2025Review
- Identification of Immune Infiltration and Iron Metabolism-Related Subgroups in Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2024Article
- FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve injury (PNI) is a major clinical problem that may lead to different levels of sensory and motor dysfunction including paralysis. Due to the high disability rate and unsatisfactory prognosis, the exploration and revealment of the mechanisms involved in the PNI are urgently required. Ferroptosis, a recently identified novel form of cell death, is an iron-dependent process. It is a unique modality of cell death, closely associated with iron concentrations, generation of reactive oxygen species, and accumulation of the lipid reactive oxygen species. These processes are regulated by multiple cellular metabolic pathways, including iron overloading, lipid peroxidation, and the glutathione/glutathione peroxidase 4 pathway. Furthermore, ferroptosis is accompanied by morphological changes in the mitochondria, such as increased membrane density and shrunken mitochondria; this association between ferroptosis and mitochondrial damage has been detected in various diseases, including spinal cord injury and PNI. The inhibition of ferroptosis can promote the repair of damaged peripheral nerves, reduce mitochondrial damage, and promote the recovery of neurological function. In this review, we intend to discuss the detailed mechanisms of ferroptosis and summarize the current researches on ferroptosis with respect to nerve injury. This review also aims at providing new insights on targeting ferroptosis for PNI treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.