Evidence map›Paper›PMID 36506834›Full record

ArticleCritical care explorations2022

Multistudy Research Operations in the ICU: An Interprofessional Pandemic-Informed Approach.

Deborah J Cook, Erick H Duan, France J Clarke, Karlo Matic, Sarah Culgin, Laurel Kelly, Katlynne S Nelson, Christine V Wallace, Mark D Soth, Kimberley A Lewis and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Deborah J CookDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Erick H DuanDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
France J ClarkeDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Karlo MaticResearch Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Sarah CulginResearch Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Laurel KellyDepartment of Physiotherapy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Katlynne S NelsonResearch Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Christine V WallaceDepartment of Pharmacy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Mark D SothDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Kimberley A LewisDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Jill C RudkowskiDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Dan PerriDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Tania L LigoriDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Roman Z JaeschkeDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Zain ChaglaDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Dipayan ChaudhuriDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Angela E WrightDepartment of Pharmacy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Zoe Y FuDepartment of Pharmacy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Brenda K ReeveDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Hilary M LeeDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Jeffrey D OveringtonDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Anna RozenbergDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Kimberly A BloomfieldDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Katryn LoveDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Jennifer L GainDepartment of Respiratory Therapy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Nicole L ZytarukDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Jason H CheungDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Lehana ThabaneResearch Institute of St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Michelle E KhoDepartment of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proliferation of COVID-19 research underscored the need for improved awareness among investigators, research staff and bedside clinicians of the operational details of clinical studies. The objective was to describe the genesis, goals, participation, procedures, and outcomes of two research operations committees in an academic ICU during the COVID-19 pandemic.

designTwo-phase, single-center multistudy cohort.

settingUniversity-affiliated ICU in Hamilton, ON, Canada. PATIENTS: Adult patients in the ICU, medical stepdown unit, or COVID-19 ward.

interventionsNone. MEASUREMENTS AND MAIN

resultsAn interprofessional COVID Collaborative was convened at the pandemic onset within our department, to proactively coordinate studies, help navigate multiple authentic consent encounters by different research staff, and determine which studies would be suitable for coenrollment. From March 2020 to May 2021, five non-COVID trials continued, two were paused then restarted, and five were launched. Over 15 months, 161 patients were involved in 215 trial enrollments, 110 (51.1%) of which were into a COVID treatment trial. The overall informed consent rate (proportion agreed of those eligible and approached including a priori and deferred consent models) was 83% (215/259). The informed consent rate was lower for COVID-19 trials (110/142, 77.5%) than other trials (105/117, 89.7%;

conclusionsStructured coordination and increased communication about research operations among diverse research stakeholders cultivated a sense of shared purpose and enhanced the integrity of clinical research operations.

Indexed as

clinical researchcritical care researchpandemicrandomized trials

Identifiers

PMID36506834
PMCPMC9722625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.