Evidence map›Paper›PMID 36506806›Full record

ArticleInnovation (Cambridge (Mass.))2023

Immune response and homeostasis mechanism following administration of BBIBP-CorV SARS-CoV-2 inactivated vaccine.

Jianhua Yin, Yingze Zhao, Fubaoqian Huang, Yunkai Yang, Yaling Huang, Zhenkun Zhuang, Yanxia Wang, Zhifeng Wang, Xiumei Lin, Yuhui Zheng and 38 more

Open access · goldAbstract read
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Human T Cell Responses to Flavivirus Vaccines.European journal of immunology · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Upregulated CD8Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 12 institutions in 1 country.

Jianhua YinBGI-Shenzhen, Shenzhen 518103, China.
Yingze ZhaoNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Fubaoqian HuangBGI-Shenzhen, Shenzhen 518103, China.
Yunkai YangChina National Biotec Group Company Limited, Beijing 100029, China.
Yaling HuangBGI-Shenzhen, Shenzhen 518103, China.
Zhenkun ZhuangBGI-Shenzhen, Shenzhen 518103, China.
Yanxia WangHenan Provincial Center for Disease Control and Prevention, Zhengzhou 450018, China.
Zhifeng WangBGI-Shenzhen, Shenzhen 518103, China.
Xiumei LinBGI-Shenzhen, Shenzhen 518103, China.
Yuhui ZhengBGI-Shenzhen, Shenzhen 518103, China.
Wenwen ZhouBGI-Shenzhen, Shenzhen 518103, China.
Shuo WangBGI-Shenzhen, Shenzhen 518103, China.
Ziqian XuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Beiwei YeNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Yaxin GuoNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Wenwen LeiNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Lei LiNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Jinmin TianNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Jinxian GanNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Hui WangBeijing Institute of Biological Products, Beijing 100176, China.
Wei WangBeijing Institute of Biological Products, Beijing 100176, China.
Peiyao MaBGI-Shenzhen, Shenzhen 518103, China.
Chang LiuBGI-Shenzhen, Shenzhen 518103, China.
Xiaoyu WeiBGI-Shenzhen, Shenzhen 518103, China.
Xuyang ShiBGI-Shenzhen, Shenzhen 518103, China.
Zifei WangBGI-Shenzhen, Shenzhen 518103, China.
Yang WangBGI-Shenzhen, Shenzhen 518103, China.
Ying LiuBGI-Shenzhen, Shenzhen 518103, China.
Mingming YangBGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.
Yue YuanBGI-Shenzhen, Shenzhen 518103, China.
Yumo SongBGI-Shenzhen, Shenzhen 518103, China.
Wen MaBGI-Shenzhen, Shenzhen 518103, China.
Zhuoli HuangBGI-Shenzhen, Shenzhen 518103, China.
Ya LiuBGI-Shenzhen, Shenzhen 518103, China.
Yunting HuangChina National GeneBank, BGI-Shenzhen, Shenzhen 518120, China.
Haorong LuChina National GeneBank, BGI-Shenzhen, Shenzhen 518120, China.
Peipei LiuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Hao LiangBiosafety Level-3 Laboratory, Life Sciences Institute & Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application, Guangxi Medical University, Nanning 530021, China.
Yong HouBGI-Shenzhen, Shenzhen 518103, China.
Xun XuBGI-Shenzhen, Shenzhen 518103, China.
Longqi LiuBGI-Shenzhen, Shenzhen 518103, China.
Yuntao ZhangChina National Biotec Group Company Limited, Beijing 100029, China.
Guizhen WuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
George F GaoNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
Xin JinBGI-Shenzhen, Shenzhen 518103, China.
Chuanyu LiuBGI-Shenzhen, Shenzhen 518103, China.
Xiaoming YangChina National Biotec Group Company Limited, Beijing 100029, China.
William J LiuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 100052, China.
BGI Group (China) · CNChinese Center For Disease Control and Prevention · CNNational Institute for Viral Disease Control and Prevention · CNUniversity of Chinese Academy of Sciences · CNChina National GeneBank · CNNational Vaccine and Serum Institute · CNSouth China University of Technology · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNGuangxi Medical University · CNHenan Provincial Center for Disease Control and Prevention · CNSouth China Agricultural University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The BBIBP-CorV severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivated vaccine has been authorized for emergency use and widely distributed. We used single-cell transcriptome sequencing to characterize the dynamics of immune responses to the BBIBP-CorV inactivated vaccine. In addition to the expected induction of humoral immunity, we found that the inactivated vaccine induced multiple, comprehensive immune responses, including significantly increased proportions of CD16

Indexed as

COVID-19homeostasisimmune responseinactivated vaccinescRNA-seq

Identifiers

PMID36506806
PMCPMC9719934
OpenAlexW4312065910

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.