Evidence map›Paper›PMID 36506792›Full record

Trial reportDrug design, development and therapy2022

Effect of Remimazolam Tosilate on Respiratory Depression in Elderly Patients Undergoing Gastroscopy: A Multicentered, Prospective, and Randomized Study.

Bailong Hu, Ke Jiang, Wenyan Shi, Shixiang Xiao, Shili Zhang, Yongguo Zhang, Yuancheng Zhou, Chengwei Tan, Songjiang Tan, Xiaohua Zou

Open access · goldAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 7 pooled it
23.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 7 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  2. RemimazolamPeerJ · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Bailong Hu *Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.ORCID 0000-0003-1126-5381
Ke Jiang *Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.
Wenyan ShiDepartment of Anesthesiology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, People's Republic of China.
Shixiang XiaoDepartment of Anesthesiology, The First People' s Hospital of Bijie City, Bijie, People's Republic of China.
Shili ZhangDepartment of Anesthesiology, Dali Bai Autonomous Prefecture People's Hospital, Dali, People's Republic of China.
Yongguo ZhangDepartment of Anesthesiology, The People's Hospital of Qiannan, Qiannan, People's Republic of China.
Yuancheng ZhouDepartment of Anesthesiology, The First People's Hospital of Guiyang, Guiyang, People's Republic of China.
Chengwei TanDepartment of Anesthesiology, The Second People's Hospital of Guiyang, Guiyang, People's Republic of China.
Songjiang TanDepartment of Anesthesiology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China.
Xiaohua ZouDepartment of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.
Guiyang Medical University · CNThe First People's Hospital of Guiyang · CNGuiyang College of Traditional Chinese Medicine · CNPeople's Hospital of Bishan District · CNQihe People's Hospital · CNThe Third People's Hospital of Dalian City · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Remimazolam tosilate (RT) is a new type of γ-aminobutyric acid subtype A (GABA Methods: This prospective, randomized, single-blinded trial recruited patients from eight centers in China between May 2022 and July 2022. A total of 346 elderly patients undergoing gastroscopy were randomly divided into RT group (0.2 mg/kg) or propofol group (1.5 mg/kg), respectively. The primary outcome was the incidence of respiratory depression. Secondary outcomes include the incidence of sedative-related adverse events, the success rate of sedation, time to fully alert, time to loss of consciousness (LOC), time to ready for discharge, as well as the the patients, endoscopists and anethetists' satisfaction. Results: The incidence of respiratory depression was significantly reduced in the RT group compared with the propofol group (9.8% vs 17.9%, P=0.042). The time of LOC and fully alert in the RT group were longer than that in the propofol group (P < 0.05). The incidences of hypotention (50.9% vs 32.4%, P=0.001) and hypotension requiring treatment (5.8% vs 1.7%, P=0.031) were significantly higher in the propofol group than that in the RT group. The incidence and severity of injection pain were more frequently recorded in the propofol group than that in the RT group (40.5% vs 12.1%, P<0.05). There were no statistically significant differences between the two groups in terms of sedation success rates, time to ready for discharge, endoscopists and anethetists' satisfaction and other sedative-related adverse events. Conclusion: RT may be a suitable alternative sedative agent for elderly patients undergoing gastroscopy due to its safety profile.

Indexed as

PropofolRespiratory InsufficiencyAgedGastroscopyHumansHypnotics and SedativesProspective StudiesHypnotics and SedativesPropofolelderly patientsgastroscopypropofolRemimazolam tosilate

Identifiers

PMID36506792
PMCPMC9733689
OpenAlexW4311503860

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.