Evidence map›Paper›PMID 36506526›Full record

ArticleFrontiers in pharmacology2022

Mitochondria-targeted antioxidant SkQ1 inhibits leukotriene synthesis in human neutrophils.

Galina F Sud'ina, Ekaterina A Golenkina, Anastasia S Prikhodko, Natalia D Kondratenko, Tatjana V Gaponova, Boris V Chernyak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Galina F Sud'inaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Ekaterina A GolenkinaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Anastasia S PrikhodkoBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Natalia D KondratenkoFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
Tatjana V GaponovaNational Research Center for Hematology, Russia Federation Ministry of Public Health, Moscow, Russia.
Boris V ChernyakBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Lomonosov Moscow State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukotrienes are among the most potent mediators of inflammation, and inhibition of their biosynthesis, is becoming increasingly important in the treatment of many pathologies. In this work, we demonstrated that preincubation of human neutrophils with the mitochondria targeted antioxidant SkQ1 (100 nM) strongly inhibits leukotriene synthesis induced by three different stimuli: the Ca

Indexed as

5-lipoxygenaseintracellular calciumleukotriene B4mitochondrianeutrophil

Identifiers

PMID36506526
PMCPMC9729262
OpenAlexW4309918933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.