Evidence map›Paper›PMID 36506088›Full record

ArticleFrontiers in cell and developmental biology2022

Reduced

Karo Talvio, Rimante Minkeviciene, Kayla G Townsley, Venkat Swaroop Achuta, Laura M Huckins, Padraic Corcoran, Kristen J Brennand, Maija L Castrén

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Astrocytes in fragile X syndrome.Frontiers in cellular neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Karo TalvioDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Rimante MinkevicieneDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Kayla G TownsleyPamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Venkat Swaroop AchutaDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Laura M HuckinsPamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Padraic CorcoranArray and Analysis Facility, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Kristen J BrennandPamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomics, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Maija L CastrénDepartment of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIAllen Institute for Brain Science · USMedical University of Vienna · ATUppsala University · SEYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lack of FMR1 protein results in fragile X syndrome (FXS), which is the most common inherited intellectual disability syndrome and serves as an excellent model disease to study molecular mechanisms resulting in neuropsychiatric comorbidities. We compared the transcriptomes of human neural progenitors (NPCs) generated from patient-derived induced pluripotent stem cells (iPSCs) of three FXS and three control male donors. Altered expression of

Indexed as

cholinergic signalingEpilepsyfragile X syndromeLYNX1neural progenitorspluripotent stem cells

Identifiers

PMID36506088
PMCPMC9731341
OpenAlexW4309788318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.