Evidence map›Paper›PMID 36506025›Full record

ArticleFrontiers in cellular and infection microbiology2022

Elevated hypertriglyceridemia and decreased gallstones in the etiological composition ratio of acute pancreatitis as affected by seasons and festivals: A two-center real-world study from China.

Wenhua He, Gang Wang, Bingjun Yu, Liang Xia, Yong Zhu, Pi Liu, Hua Chen, Rui Kong, Yin Zhu, Bei Sun and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07720232 (Effect of Bacillus Subtilis and Enterococcus Faecium Combination Therapy Combined With Conventional Lipid-Lowering Treatment on Triglyceride Levels in Patients With Hypertriglyceridemic Acute Pancreatitis), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07720232 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Bacillus Subtilis and Enterococcus Faecium Combination Therapy Combined With Conventional Lipid-Lowering Treatment on Triglyceride Levels in Patients With Hypertriglyceridemic Acute Pancreatitis: A Prospective Randomized Controlled Trial

TypeinterventionalSponsorJianyin ZhouRan2026 to 2029Enrolled180ConditionsHypertriglyceridemic Acute Pancreatitis, Acute Pancreatitis, Hypertriglyceridemia-induced, HyperlipidemiaArmsLive Combined Bacillus subtilis and Enterococcus faecium Enteric-coated Capsules (LCBE), Standard Care (in control arm)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  6. Article
  7. Article
  8. Stimulation of Skin Pigmentation with UVR Is a Risk Factor for Cholelithiasis.JID innovations : skin science from molecules to population health · 2025
    Review
  9. Hypertriglyceridemic pancreatitis: perspectives from China.Current opinion in gastroenterology · 2025
    Review
  10. Article
  11. [Early Predictors for Hypertriglyceridemic Acute Pancreatitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Wenhua HeDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Gang WangDepartment of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bingjun YuDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Liang XiaDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yong ZhuDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Pi LiuDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Hua ChenDepartment of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Rui KongDepartment of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yin ZhuDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Bei SunDepartment of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Nonghua LuDepartment of Gastroenterology, Pancreatic Disease Centre, The First Affiliated Hospital of Nanchang University, Nanchang, China.
First Affiliated Hospital of Nanchang University · CNFirst Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this study was to observe the annual variation in the etiology of acute pancreatitis (AP) and its relationship with seasons and festivals. Methods: From 2011 to 2017, 5146 adult patients with AP were studied, including 4110 patients from the First Affiliated Hospital of Nanchang University (South center) and 1036 patients from the First Affiliated Hospital of Harbin Medical University (North center). We analyzed the overall annual variation in the etiology of AP and then compared the differences in etiology between the two regions, as well as the effects of seasons and festivals on the etiology of AP. Results: Gallstones, hypertriglyceridemia (HTG) and alcohol were the top three etiologies of AP. Gallstone AP showed a downward trend (P<0.001), and HTG-AP and alcohol AP showed an upward trend (both P<0.01). Among the etiologies of AP, gallstones and HTG were affected by seasons and festivals. The composition ratio of HTG-AP increased, while gallstone AP decreased in winter and in months with long holidays (all P<0.01). The composition ratio of gallstone AP in the south center was higher than that in the north center (59.5% vs. 49%), especially in summer (62.9% vs. 44.0%) and autumn (61.5% vs. 45.7%, all P<0.001). Conclusions: The composition ratio of HTG-AP increased while gallstone AP decreased in the past 7 years, and they were affected by seasons and festivals.

Indexed as

HypertriglyceridemiaPancreatitisAcute DiseaseAdultChinaEthanolHumansSeasonsEthanolacute pancreatitisepidemiologyetiologyhypertriglyceridemiaseason

Identifiers

PMID36506025
PMCPMC9730824
OpenAlexW4309915800

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.