Evidence map›Paper›PMID 36506010›Full record

Trial reportFrontiers in cellular and infection microbiology2022

Use of N-acetylcysteine as treatment adjuvant regulates immune response in visceral leishmaniasis: Pilot clinical trial and

Lucas Sousa Magalhães, Enaldo Vieira Melo, Nayra Prata Damascena, Adriana Cardoso Batista Albuquerque, Camilla Natália Oliveira Santos, Mônica Cardozo Rebouças, Mariana de Oliveira Bezerra, Ricardo Louzada da Silva, Fabricia Alvisi de Oliveira, Priscila Lima Santos and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lucas Sousa MagalhãesLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Enaldo Vieira MeloDepartment of Medicine, University Hospital-Empresa Brasileira de Serviços Hospitalares (EBSERH), Federal University of Sergipe, Aracaju, Brazil.
Nayra Prata DamascenaDepartment of Medicine, University Hospital-Empresa Brasileira de Serviços Hospitalares (EBSERH), Federal University of Sergipe, Aracaju, Brazil.
Adriana Cardoso Batista AlbuquerqueDepartment of Medicine, University Hospital-Empresa Brasileira de Serviços Hospitalares (EBSERH), Federal University of Sergipe, Aracaju, Brazil.
Camilla Natália Oliveira SantosLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Mônica Cardozo RebouçasLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Mariana de Oliveira BezerraLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Ricardo Louzada da SilvaLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Fabricia Alvisi de OliveiraLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Priscila Lima SantosLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
João Santana da SilvaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Michael Wheeler LipscombDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, United States.
Ângela Maria da SilvaLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Amélia Ribeiro de JesusLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Roque Pacheco de AlmeidaLaboratory of Immunology and Molecular Biology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This investigation aimed to assess the effect of N-acetylcysteine (NAC) as an adjuvant treatment to alleviate visceral leishmaniasis (VL). The present work includes both blinded randomized clinical intervention and experimental

Indexed as

Leishmania infantumLeishmaniasis, VisceralAcetylcysteineAdjuvants, ImmunologicHumansImmunityInterleukin-10Leukocytes, MononuclearAcetylcysteineAdjuvants, ImmunologicInterleukin-10adjuvant chemotherapydrug therapymeglumine antimoniateN-acetyl-l-cysteinevisceral leishmaniasis

Identifiers

PMID36506010
PMCPMC9730326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.