Evidence map›Paper›PMID 36505955›Full record

ArticleCureus2022

Ototoxicity of Triclosan: A Rat Model Study.

Çağlar Günebakan, Orhan K Kahveci, Selçuk Kuzu, Emine H Kandır

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Çağlar GünebakanOtolaryngology - Head and Neck Surgery, Afyonkarahisar Health Sciences University, Afyonkarahisar, TUR.
Orhan K KahveciOtolaryngology - Head and Neck Surgery, Afyonkarahisar Health Sciences University, Afyonkarahisar, TUR.
Selçuk KuzuOtolaryngology - Head and Neck Surgery, Afyonkarahisar Health Sciences University, Afyonkarahisar, TUR.
Emine H KandırFaculty of Veterinary Medicine, Department of Wildlife and Ecology, Afyon Kocatepe University, Afyonkarahisar, TUR.
Afyon Kocatepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTriclosan is utilized as an antibacterial factor in many industrial products. Although there are many toxic features of triclosan in the literature, there is no study on the effect of triclosan on hearing. The purpose of this study is to determine the effect of triclosan on hearing in rats.

methodsIn this prospective, experimental animal study, 40 healthy Sprague-Dawley rats with normal response to the distortion-product otoacoustic emission (DPOAE) measurements were divided into four groups. Group 1, as the control group, was given only corn oil, group 2 was given 5 mg/kg triclosan dissolved in corn oil, group 3 was given 10 mg/kg triclosan dissolved in corn oil, and group 4 was given 100 mg/kg triclosan dissolved in corn oil; triclosan and corn oil were administered by oral gavage to all groups.

resultsIn our study, low-dose triclosan did not cause hearing loss, but hearing loss was observed in the group that was given high-dose triclosan (100 mg/kg).

conclusionThese findings suggest that triclosan causes hearing loss in rats. This issue should be investigated further to avoid triclosan ototoxicity in humans.

Indexed as

dose-dependanthearing lossototoxicityrat modeltriclosan

Identifiers

PMID36505955
PMCPMC9728979
OpenAlexW4311287633

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.