ArticleEuropean clinical respiratory journal2023
Hypoxemia and not hyperoxemia predicts worse outcome in severe COPD exacerbations - an observational study.
Article in European clinical respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Prevalence of Exercise-Induced Desaturation Among COPD Patients Enrolled in Early Inpatient Pulmonary Rehabilitation.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Synergistic Effects of Integrating Fire Dragon Cupping with Non-Invasive Ventilation on Lung Function and Inflammatory Response in COPD Patients with Hypoxemia: A Single-Center Retrospective Study.Journal of inflammation research · 2026Article
- Serum electrolytes as prognostic markers: a new frontier in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) management.Journal of thoracic disease · 2025Article
- Prediction of 12-month exacerbation-related readmission in hospitalized patients with COPD: a single-center study in China.European journal of medical research · 2025Article
- Article
- Oxygen Therapy in COPD.Respiratory care · 2023Article
- COPD Exacerbation: Why It Is Important to Avoid ICU Admission.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: For patients admitted with an acute exacerbation of COPD (AECOPD) and a need for supplementary oxygen therapy, to determine if peripheral oxygen saturation < 88% (hypoxemia) or >92% (hyperoxemia), within first 24 hours of admission, is associated with 'treatment failure' or fewer days alive and out of hospital within 14 days after admission. Design: A retrospective multicenter observational study, reviewing consecutive data on SpO2, oxygen, and drug administration at three predefined time points, on adverse events in patients admitted with COPD between December 2019 and June 2020. Multivariable logistic regression analysis, Mann Whitney U- and Chi-square-test were used. Setting: Acute hospital setting, across four different hospitals in the capital region of Denmark. Participants: Patients with a confirmed diagnosis of COPD admitted with an acute exacerbation and an oxygen need within the first 24 hours admission. Results: In total 289 COPD patients were included. The median age was 74.8 years [interquartile range (IQR):69.6 to 81.8], 191 were female and 132 patients experienced 'treatment failure'. A minimum of one episode of hypoxemia (SpO Conclusion: For admitted patients with AECOPD, being hypoxemic ever within the first 24 hours after admission is associated with a substantially increased risk of a poor prognosis.
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Registered trials
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