ArticleFrontiers in cardiovascular medicine2022
Numerical study of the risk of thrombosis in the left atrial appendage of chicken wing shape in atrial fibrillation.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 13 citations in OpenAlex.
- Thromboembolism in the left atrial appendage under atrial fibrillation and after sinus rhythm restoration: a computational study.Frontiers in bioengineering and biotechnology · 2026Article
- CFD-derived radiomics from hemodynamic maps for quantitative assessment of left atrial flow in atrial fibrillation: a proof-of-concept study.Frontiers in cardiovascular medicine · 2026Article
- Translation of Animal Study to Human: In Silico Based Development of Implantable Pulmonary Artery Pressure Sensor.International journal for numerical methods in biomedical engineering · 2025Article
- The impact of contrast retention on thrombus formation risks in patients with atrial fibrillation: A numerical study.Heliyon · 2024Article
- Research on the Internal Flow Field of Left Atrial Appendage and Stroke Risk Assessment with Different Blood Models.Bioengineering (Basel, Switzerland) · 2023Article
- In-silico enhanced animal study of pulmonary artery pressure sensors: assessing hemodynamics using computational fluid dynamics.Frontiers in cardiovascular medicine · 2023Article
- Use of a new non-contrast-enhanced BOOST cardiac MR sequence before electrical cardioversion or ablation of atrial fibrillation-a pilot study.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) is a common and life-threatening disease. For the patients with AF, more than 90% of the thrombi are formed in the left atrial appendage (LAA), thrombus dislodgement can cause vascular embolism, making them is becoming a high-risk group for stroke. Therefore, identifying the patients with high risk of thrombosis is crucial for advanced stroke warning. To better investigate the mechanism behind thrombus formation in the LAA, this study reconstructed the 3-D Left Atrium (LA) models of six AF volunteer patients by corresponding Computed Tomography (CT) images. Combine the advantages of Computational Fluid Dynamics (CFD), the blood flow field in LA both in AF and sinus heart rate states were studied. The risk of thrombus was evaluated based on the blood viscosity, shear rate thrombus prediction model and Time Average Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI), and Relative Residence Time (RRT) values. The results showed that the left atrium had lower blood flow velocity and TAWSS values at the LAA in both AF and sinus rhythm, thus the LAA is the most thrombogenic region in the LA. Besides, the RRT value of LAA was generally higher in AF than in sinus rhythm. Therefore, AF carries a higher risk of thrombosis.
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