Value of plasma vitamin D level and nomogram model for predicting the prognosis of patients with small cell lung cancer treated with platinum plus etoposide as first-line chemotherapy.

Xiaochang Zhang, Wei Li, Yonghua Liu, Linglong Xu, Xu Wang, Xiaoning Feng

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Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Relationship between preoperative body mass index and overall mortality in patients who have undergone lobectomy for lung cancer.World journal of surgical oncology · 2025
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6 authors.

Xiaochang ZhangDepartment of Hematology and Oncology, Taizhou Central Hospital (Taizhou University Hospital) Taizhou 318000, Zhejiang, P. R. China.

Wei LiCancer and Stem Cell Center, First Affiliated Hospital, Jilin University Changchun 130061, Jilin, P. R. China.

Yonghua LiuDepartment of Hematology, Lishui People's Hospital Lishui 323000, Zhejiang, P. R. China.

Linglong XuDepartment of Hematology and Oncology, Taizhou Central Hospital (Taizhou University Hospital) Taizhou 318000, Zhejiang, P. R. China.

Xu WangCancer and Stem Cell Center, First Affiliated Hospital, Jilin University Changchun 130061, Jilin, P. R. China.

Xiaoning FengDepartment of Hematology, Lishui People's Hospital Lishui 323000, Zhejiang, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the value of plasma vitamin D level and nomogram model in predicting the prognosis of patients with small cell lung cancer (SCLC) treated with platinum plus etoposide (PPE) as first-line chemotherapy.

methodsIn this retrospective study, we included 178 patients with SCLC. The data of 25(OH)D level, basic clinical information, overall survival (OS) and progression-free survival (PFS) were collected. Moreover, a nomogram was constructed to predict the prognosis of the patients.

resultsThe median OS value for patients with 25(OH)D < 10 ng/mL was 12.5 months. The median PFS value was 6.6 months. Sex, smoking status, clinical stage, and plasma vitamin D were independent prognostic predictors. Besides, the decision curve analysis and receiver operating characteristic curve indicated that the nomogram prediction models showed positive clinical benefit.

conclusionsThe plasma vitamin D level is of great significance in prognosis of patients with SCLC. The construction of nomograms is beneficial in predicting the prognosis of patients with SCLC treated with PPE.

Indexed as

nomogramprognostic factorsmall cell lung cancersurvivalVitamin D level

Identifiers

PMID36505322

PMCPMC9730104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.